A mutation in the hepatocyte nuclear factor-4α (HNF-4a) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4α gene) was searched in 514 alleles of Japanese NIDDM patients by polymerase chain reaction-restriction fragment length polymorphism analysis. No mutation was found in these patients. The result showed that the Q268X mutation of HNF-4α gene was not frequent among general NIDDM patients and that it cannot serve as the major diabetogenic gene in the Japanese ethnic group.
|Number of pages||4|
|Journal||Research Communications in Molecular Pathology and Pharmacology|
|Publication status||Published - 12-1996|
All Science Journal Classification (ASJC) codes
- Molecular Medicine