Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients

Hiromu Nakajima; Issei Yoshiuchi; Tomoya Hamaguchi; Koji Tomita; Tomoyuki Yamasaki; Katsumi Iizuka; Kohei Okita; Makoto Moriwaki; Akira Ono; Takanori Oue; Yukio Horikawa; Ryosuke Shingu; Jun Ichiro Miyagawa; Mitsuyoshi Namba; Toshiaki Hanafusa; Yuji Matsuzawa

Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients

Hiromu Nakajima, Issei Yoshiuchi, Tomoya Hamaguchi, Koji Tomita, Tomoyuki Yamasaki, Katsumi Iizuka, Kohei Okita, Makoto Moriwaki, Akira Ono, Takanori Oue, Yukio Horikawa, Ryosuke Shingu, Jun Ichiro Miyagawa, Mitsuyoshi Namba, Toshiaki Hanafusa, Yuji Matsuzawa

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A mutation in the hepatocyte nuclear factor-4α (HNF-4a) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4α gene) was searched in 514 alleles of Japanese NIDDM patients by polymerase chain reaction-restriction fragment length polymorphism analysis. No mutation was found in these patients. The result showed that the Q268X mutation of HNF-4α gene was not frequent among general NIDDM patients and that it cannot serve as the major diabetogenic gene in the Japanese ethnic group.

Original language	English
Pages (from-to)	327-330
Number of pages	4
Journal	Research Communications in Molecular Pathology and Pharmacology
Volume	94
Issue number	3
Publication status	Published - 12-1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nakajima, H., Yoshiuchi, I., Hamaguchi, T., Tomita, K., Yamasaki, T., Iizuka, K., Okita, K., Moriwaki, M., Ono, A., Oue, T., Horikawa, Y., Shingu, R., Miyagawa, J. I., Namba, M., Hanafusa, T., & Matsuzawa, Y. (1996). Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients. Research Communications in Molecular Pathology and Pharmacology, 94(3), 327-330.

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title = "Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients",

abstract = "A mutation in the hepatocyte nuclear factor-4α (HNF-4a) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4α gene) was searched in 514 alleles of Japanese NIDDM patients by polymerase chain reaction-restriction fragment length polymorphism analysis. No mutation was found in these patients. The result showed that the Q268X mutation of HNF-4α gene was not frequent among general NIDDM patients and that it cannot serve as the major diabetogenic gene in the Japanese ethnic group.",

author = "Hiromu Nakajima and Issei Yoshiuchi and Tomoya Hamaguchi and Koji Tomita and Tomoyuki Yamasaki and Katsumi Iizuka and Kohei Okita and Makoto Moriwaki and Akira Ono and Takanori Oue and Yukio Horikawa and Ryosuke Shingu and Miyagawa, {Jun Ichiro} and Mitsuyoshi Namba and Toshiaki Hanafusa and Yuji Matsuzawa",

year = "1996",

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language = "English",

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pages = "327--330",

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}

Nakajima, H, Yoshiuchi, I, Hamaguchi, T, Tomita, K, Yamasaki, T, Iizuka, K, Okita, K, Moriwaki, M, Ono, A, Oue, T, Horikawa, Y, Shingu, R, Miyagawa, JI, Namba, M, Hanafusa, T & Matsuzawa, Y 1996, 'Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients', Research Communications in Molecular Pathology and Pharmacology, vol. 94, no. 3, pp. 327-330.

TY - JOUR

T1 - Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients

AU - Nakajima, Hiromu

AU - Yoshiuchi, Issei

AU - Hamaguchi, Tomoya

AU - Tomita, Koji

AU - Yamasaki, Tomoyuki

AU - Iizuka, Katsumi

AU - Okita, Kohei

AU - Moriwaki, Makoto

AU - Ono, Akira

AU - Oue, Takanori

AU - Horikawa, Yukio

AU - Shingu, Ryosuke

AU - Miyagawa, Jun Ichiro

AU - Namba, Mitsuyoshi

AU - Hanafusa, Toshiaki

AU - Matsuzawa, Yuji

PY - 1996/12

Y1 - 1996/12

N2 - A mutation in the hepatocyte nuclear factor-4α (HNF-4a) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4α gene) was searched in 514 alleles of Japanese NIDDM patients by polymerase chain reaction-restriction fragment length polymorphism analysis. No mutation was found in these patients. The result showed that the Q268X mutation of HNF-4α gene was not frequent among general NIDDM patients and that it cannot serve as the major diabetogenic gene in the Japanese ethnic group.

AB - A mutation in the hepatocyte nuclear factor-4α (HNF-4a) gene has been recently reported to cause maturity-onset diabetes of the young (MODY) (Yamagata, Furuta, et al., 1996). The mutation can also be a good candidate for the responsible gene of non-insulin dependent diabetes mellitus (NIDDM). The existence of the mutated allele of Q268X (C to T substitution within the exon 7 of HNF-4α gene) was searched in 514 alleles of Japanese NIDDM patients by polymerase chain reaction-restriction fragment length polymorphism analysis. No mutation was found in these patients. The result showed that the Q268X mutation of HNF-4α gene was not frequent among general NIDDM patients and that it cannot serve as the major diabetogenic gene in the Japanese ethnic group.

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SN - 1078-0297

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JO - Research Communications in Molecular Pathology and Pharmacology

JF - Research Communications in Molecular Pathology and Pharmacology

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ER -

Hepatocyte nuclear factor-4α gene mutations in Japanese non-insulin dependent diabetes mellitus (NIDDM) patients

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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