Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy

T. S. Kato, Hideo Izawa, K. Komamura, A. Noda, H. Asano, K. Nagata, S. Hashimoto, N. Oda, C. Kamiya, H. Kanzaki, K. Hashimura, H. I. Ueda, T. Murohara, M. Kitakaze, M. Yokota

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVWT) in patients with hypertrophic cardiomyopathy (HCM). Design and setting: Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Participants: Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Main outcome measures: Conventional echocardio-graphy and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (ε sys), peak systolic SR (SRsys), peak early diastolic SR (SRdia) and LVWT were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity micromanometer. Results: The regional εsys and SRsys were correlated with LVWT in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVWT, εsys and SRsys obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of εsys and SRsys (/- = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVWT, εsys and SRsys were correlated with tau (r = 0.35, p<0.05; r = 0.47, p<O.001; and r = 0.39, p<0.005, respectively). Conclusions: Heterogeneity of regional LV systolic function detected by SR imaging is in part attributable to heterogeneity of LVH and may be linked to impaired global LV relaxation in HCM.

Original languageEnglish
Pages (from-to)1302-1306
Number of pages5
JournalHeart
Volume94
Issue number10
DOIs
Publication statusPublished - 01-10-2008

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Hypertrophic Cardiomyopathy
Hypertrophy
Left Ventricular Function
Left Ventricular Hypertrophy
Ventricular Pressure
Observational Studies
Japan
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Kato, T. S. ; Izawa, Hideo ; Komamura, K. ; Noda, A. ; Asano, H. ; Nagata, K. ; Hashimoto, S. ; Oda, N. ; Kamiya, C. ; Kanzaki, H. ; Hashimura, K. ; Ueda, H. I. ; Murohara, T. ; Kitakaze, M. ; Yokota, M. / Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy. In: Heart. 2008 ; Vol. 94, No. 10. pp. 1302-1306.
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title = "Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy",
abstract = "Objective: To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVWT) in patients with hypertrophic cardiomyopathy (HCM). Design and setting: Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Participants: Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Main outcome measures: Conventional echocardio-graphy and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (ε sys), peak systolic SR (SRsys), peak early diastolic SR (SRdia) and LVWT were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity micromanometer. Results: The regional εsys and SRsys were correlated with LVWT in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVWT, εsys and SRsys obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of εsys and SRsys (/- = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVWT, εsys and SRsys were correlated with tau (r = 0.35, p<0.05; r = 0.47, p<O.001; and r = 0.39, p<0.005, respectively). Conclusions: Heterogeneity of regional LV systolic function detected by SR imaging is in part attributable to heterogeneity of LVH and may be linked to impaired global LV relaxation in HCM.",
author = "Kato, {T. S.} and Hideo Izawa and K. Komamura and A. Noda and H. Asano and K. Nagata and S. Hashimoto and N. Oda and C. Kamiya and H. Kanzaki and K. Hashimura and Ueda, {H. I.} and T. Murohara and M. Kitakaze and M. Yokota",
year = "2008",
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doi = "10.1136/hrt.2007.124453",
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Kato, TS, Izawa, H, Komamura, K, Noda, A, Asano, H, Nagata, K, Hashimoto, S, Oda, N, Kamiya, C, Kanzaki, H, Hashimura, K, Ueda, HI, Murohara, T, Kitakaze, M & Yokota, M 2008, 'Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy', Heart, vol. 94, no. 10, pp. 1302-1306. https://doi.org/10.1136/hrt.2007.124453

Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy. / Kato, T. S.; Izawa, Hideo; Komamura, K.; Noda, A.; Asano, H.; Nagata, K.; Hashimoto, S.; Oda, N.; Kamiya, C.; Kanzaki, H.; Hashimura, K.; Ueda, H. I.; Murohara, T.; Kitakaze, M.; Yokota, M.

In: Heart, Vol. 94, No. 10, 01.10.2008, p. 1302-1306.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Heterogeneity of regional systolic function detected by tissue Doppler imaging is linked to impaired global left ventricular relaxation in hypertrophic cardiomyopathy

AU - Kato, T. S.

AU - Izawa, Hideo

AU - Komamura, K.

AU - Noda, A.

AU - Asano, H.

AU - Nagata, K.

AU - Hashimoto, S.

AU - Oda, N.

AU - Kamiya, C.

AU - Kanzaki, H.

AU - Hashimura, K.

AU - Ueda, H. I.

AU - Murohara, T.

AU - Kitakaze, M.

AU - Yokota, M.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Objective: To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVWT) in patients with hypertrophic cardiomyopathy (HCM). Design and setting: Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Participants: Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Main outcome measures: Conventional echocardio-graphy and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (ε sys), peak systolic SR (SRsys), peak early diastolic SR (SRdia) and LVWT were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity micromanometer. Results: The regional εsys and SRsys were correlated with LVWT in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVWT, εsys and SRsys obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of εsys and SRsys (/- = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVWT, εsys and SRsys were correlated with tau (r = 0.35, p<0.05; r = 0.47, p<O.001; and r = 0.39, p<0.005, respectively). Conclusions: Heterogeneity of regional LV systolic function detected by SR imaging is in part attributable to heterogeneity of LVH and may be linked to impaired global LV relaxation in HCM.

AB - Objective: To evaluate regional and global left ventricular (LV) function and LV wall thickness (LVWT) in patients with hypertrophic cardiomyopathy (HCM). Design and setting: Observational study at the National Cardiovascular Centre and Nagoya University Hospital in Japan. Participants: Thirty-six patients with HCM and 16 patients with hypertensive LV hypertrophy (LVH). Main outcome measures: Conventional echocardio-graphy and strain rate (SR) imaging derived from tissue Doppler imaging were performed. Systolic strain (ε sys), peak systolic SR (SRsys), peak early diastolic SR (SRdia) and LVWT were obtained from eight LV segments. LV pressure was simultaneously recorded with a high-fidelity micromanometer. Results: The regional εsys and SRsys were correlated with LVWT in patients with HCM (r = 0.50, p<0.001 and r = 0.63, p<0.001, respectively) but not in patients with hypertensive LVH. The standard deviations of LVWT, εsys and SRsys obtained from the eight LV segments of each subject were greater for patients with HCM than for patients with hypertensive LVH. The standard deviation of LVWT was correlated with those of εsys and SRsys (/- = 0.55, p<0.001 and r = 0.56, p<0.001, respectively). The standard deviations of LVWT, εsys and SRsys were correlated with tau (r = 0.35, p<0.05; r = 0.47, p<O.001; and r = 0.39, p<0.005, respectively). Conclusions: Heterogeneity of regional LV systolic function detected by SR imaging is in part attributable to heterogeneity of LVH and may be linked to impaired global LV relaxation in HCM.

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U2 - 10.1136/hrt.2007.124453

DO - 10.1136/hrt.2007.124453

M3 - Article

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AN - SCOPUS:52649159203

VL - 94

SP - 1302

EP - 1306

JO - Heart

JF - Heart

SN - 1355-6037

IS - 10

ER -