HF10, an attenuated herpes simplex virus (HSV) type 1 clone, lacks neuroinvasiveness and protects mice against lethal challenge with HSV types 1 and 2

Isamu Mori, Beixing Liu, Fumi Goshima, Hiroyasu Ito, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi, Yoshinobu Kimura, Yukihiro Nishiyama

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Herpes simplex virus (HSV), a neurotropic virus, establishes life-long and, although rare, life-threatening infection in humans, and it may precipitate substantial medical and psychosocial morbidity. Here we show that HSV-1 strain HF clone 10 (HF10) exhibits impaired neuroinvasiveness in peripheral olfactory, vomeronasal and trigeminal conduits following intranasal as well as corneal inoculation. HF10 attenuation likely arises from multiple defects of HSV genes, so that HF10 will not revert to a virulent phenotype. Intranasal vaccination of mice with HF10 conferred significant protection against lethal challenge with HSV-1 and HSV-2 via the intranasal and intravaginal routes. Thus, we propose that HF10 explicitly meets the prerequisites for a candidate live attenuated HSV vaccine.

Original languageEnglish
Pages (from-to)1492-1500
Number of pages9
JournalMicrobes and Infection
Volume7
Issue number15
DOIs
Publication statusPublished - 12-2005

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Infectious Diseases

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