Abstract
Primary human herpesvirus (HHV)-6B and HHV-7 infections can cause exanthem subitum, which is a common febrile exanthematous disease in childhood. Additionally, reactivation of the viruses has been implicated in skin manifestations. There are different incidence rates of exanthem subitum among patients with primary HHV-6B or HHV-7 infection in Japan and the United States. This disease is generally a benign, self-limiting disease, and it rarely causes complications such as febrile seizures and encephalitis. HHV-6B and HHV-7 reactivate in patients with drug-induced hypersensitivity syndrome (DIHS)/drug reaction with eosinophilia and systemic symptom (DRES), which has the clinical triad of fever, rash, and internal organ involvement due to drug exposure. Additionally, HHV-6B reactivation was associated with fever and skin rash or acute graft-versus-host disease in hematopoietic stem cell transplantation.
Original language | English |
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Title of host publication | Human Herpesviruses HHV-6A, HHV-6B, and HHV-7, Third Edition |
Publisher | Elsevier B.V. |
Pages | 153-166 |
Number of pages | 14 |
ISBN (Print) | 9780444627032 |
DOIs | |
Publication status | Published - 03-2014 |
All Science Journal Classification (ASJC) codes
- General Immunology and Microbiology