High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns

Mohamed Hamed Hussein; Ghada A. Daoud; Hiroki Kakita; Shin Kato; Tatenobu Goto; Michi Kamei; Kenji Goto; Masanori Nobata; Yasuhiko Ozaki; Tetsuya Ito; Sumio Fukuda; Ineko Kato; Satoshi Suzuki; Hisanori Sobajima; Fujio Hara; Takashi Hashimoto; Hajime Togari

doi:10.3109/10715760903548245

High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns

Mohamed Hamed Hussein, Ghada A. Daoud, Hiroki Kakita, Shin Kato, Tatenobu Goto, Michi Kamei, Kenji Goto, Masanori Nobata, Yasuhiko Ozaki, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Satoshi Suzuki, Hisanori Sobajima, Fujio Hara, Takashi Hashimoto, Hajime Togari

Pediatrics

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5^th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.

Original language	English
Pages (from-to)	422-429
Number of pages	8
Journal	Free Radical Research
Volume	44
Issue number	4
DOIs	https://doi.org/10.3109/10715760903548245
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Biochemistry

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Hussein, M. H., Daoud, G. A., Kakita, H., Kato, S., Goto, T., Kamei, M., Goto, K., Nobata, M., Ozaki, Y., Ito, T., Fukuda, S., Kato, I., Suzuki, S., Sobajima, H., Hara, F., Hashimoto, T., & Togari, H. (2010). High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. Free Radical Research, 44(4), 422-429. https://doi.org/10.3109/10715760903548245

Hussein, Mohamed Hamed ; Daoud, Ghada A. ; Kakita, Hiroki ; Kato, Shin ; Goto, Tatenobu ; Kamei, Michi ; Goto, Kenji ; Nobata, Masanori ; Ozaki, Yasuhiko ; Ito, Tetsuya ; Fukuda, Sumio ; Kato, Ineko ; Suzuki, Satoshi ; Sobajima, Hisanori ; Hara, Fujio ; Hashimoto, Takashi ; Togari, Hajime. / High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. In: Free Radical Research. 2010 ; Vol. 44, No. 4. pp. 422-429.

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abstract = "The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.",

author = "Hussein, {Mohamed Hamed} and Daoud, {Ghada A.} and Hiroki Kakita and Shin Kato and Tatenobu Goto and Michi Kamei and Kenji Goto and Masanori Nobata and Yasuhiko Ozaki and Tetsuya Ito and Sumio Fukuda and Ineko Kato and Satoshi Suzuki and Hisanori Sobajima and Fujio Hara and Takashi Hashimoto and Hajime Togari",

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Hussein, MH, Daoud, GA, Kakita, H, Kato, S, Goto, T, Kamei, M, Goto, K, Nobata, M, Ozaki, Y, Ito, T, Fukuda, S, Kato, I, Suzuki, S, Sobajima, H, Hara, F, Hashimoto, T & Togari, H 2010, 'High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns', Free Radical Research, vol. 44, no. 4, pp. 422-429. https://doi.org/10.3109/10715760903548245

High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. / Hussein, Mohamed Hamed; Daoud, Ghada A.; Kakita, Hiroki; Kato, Shin; Goto, Tatenobu; Kamei, Michi; Goto, Kenji; Nobata, Masanori; Ozaki, Yasuhiko; Ito, Tetsuya; Fukuda, Sumio; Kato, Ineko; Suzuki, Satoshi; Sobajima, Hisanori; Hara, Fujio; Hashimoto, Takashi; Togari, Hajime.

In: Free Radical Research, Vol. 44, No. 4, 2010, p. 422-429.

Research output: Contribution to journal › Article

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AU - Hussein, Mohamed Hamed

AU - Daoud, Ghada A.

AU - Kakita, Hiroki

AU - Kato, Shin

AU - Goto, Tatenobu

AU - Kamei, Michi

AU - Goto, Kenji

AU - Nobata, Masanori

AU - Ozaki, Yasuhiko

AU - Ito, Tetsuya

AU - Fukuda, Sumio

AU - Kato, Ineko

AU - Suzuki, Satoshi

AU - Sobajima, Hisanori

AU - Hara, Fujio

AU - Hashimoto, Takashi

AU - Togari, Hajime

PY - 2010

Y1 - 2010

N2 - The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.

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