TY - JOUR
T1 - High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns
AU - Hussein, Mohamed Hamed
AU - Daoud, Ghada A.
AU - Kakita, Hiroki
AU - Kato, Shin
AU - Goto, Tatenobu
AU - Kamei, Michi
AU - Goto, Kenji
AU - Nobata, Masanori
AU - Ozaki, Yasuhiko
AU - Ito, Tetsuya
AU - Fukuda, Sumio
AU - Kato, Ineko
AU - Suzuki, Satoshi
AU - Sobajima, Hisanori
AU - Hara, Fujio
AU - Hashimoto, Takashi
AU - Togari, Hajime
PY - 2010
Y1 - 2010
N2 - The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.
AB - The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.
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U2 - 10.3109/10715760903548245
DO - 10.3109/10715760903548245
M3 - Article
C2 - 20166885
AN - SCOPUS:77949404620
VL - 44
SP - 422
EP - 429
JO - Free Radical Research
JF - Free Radical Research
SN - 1071-5762
IS - 4
ER -