High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns

Mohamed Hamed Hussein, Ghada A. Daoud, Hiroki Kakita, Shin Kato, Tatenobu Goto, Michi Kamei, Kenji Goto, Masanori Nobata, Yasuhiko Ozaki, Tetsuya Ito, Sumio Fukuda, Ineko Kato, Satoshi Suzuki, Hisanori Sobajima, Fujio Hara, Takashi Hashimoto, Hajime Togari

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, totalhydroperoxide (TH), biological-antioxidant- potentials (BAPs), 12 cytokines and Erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.

Original languageEnglish
Pages (from-to)422-429
Number of pages8
JournalFree Radical Research
Volume44
Issue number4
DOIs
Publication statusPublished - 19-03-2010

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Cerebrospinal fluid
Brain Hypoxia
Interleukin-8
Cerebrospinal Fluid
Erythropoietin
Brain
Antioxidants
Brain Injuries
Dilution
Oxidative stress
Phosphopyruvate Hydratase
Oxidative Stress
Cytokines

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Hussein, M. H., Daoud, G. A., Kakita, H., Kato, S., Goto, T., Kamei, M., ... Togari, H. (2010). High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. Free Radical Research, 44(4), 422-429. https://doi.org/10.3109/10715760903548245
Hussein, Mohamed Hamed ; Daoud, Ghada A. ; Kakita, Hiroki ; Kato, Shin ; Goto, Tatenobu ; Kamei, Michi ; Goto, Kenji ; Nobata, Masanori ; Ozaki, Yasuhiko ; Ito, Tetsuya ; Fukuda, Sumio ; Kato, Ineko ; Suzuki, Satoshi ; Sobajima, Hisanori ; Hara, Fujio ; Hashimoto, Takashi ; Togari, Hajime. / High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. In: Free Radical Research. 2010 ; Vol. 44, No. 4. pp. 422-429.
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Hussein, MH, Daoud, GA, Kakita, H, Kato, S, Goto, T, Kamei, M, Goto, K, Nobata, M, Ozaki, Y, Ito, T, Fukuda, S, Kato, I, Suzuki, S, Sobajima, H, Hara, F, Hashimoto, T & Togari, H 2010, 'High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns', Free Radical Research, vol. 44, no. 4, pp. 422-429. https://doi.org/10.3109/10715760903548245

High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. / Hussein, Mohamed Hamed; Daoud, Ghada A.; Kakita, Hiroki; Kato, Shin; Goto, Tatenobu; Kamei, Michi; Goto, Kenji; Nobata, Masanori; Ozaki, Yasuhiko; Ito, Tetsuya; Fukuda, Sumio; Kato, Ineko; Suzuki, Satoshi; Sobajima, Hisanori; Hara, Fujio; Hashimoto, Takashi; Togari, Hajime.

In: Free Radical Research, Vol. 44, No. 4, 19.03.2010, p. 422-429.

Research output: Contribution to journalArticle

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AU - Hussein, Mohamed Hamed

AU - Daoud, Ghada A.

AU - Kakita, Hiroki

AU - Kato, Shin

AU - Goto, Tatenobu

AU - Kamei, Michi

AU - Goto, Kenji

AU - Nobata, Masanori

AU - Ozaki, Yasuhiko

AU - Ito, Tetsuya

AU - Fukuda, Sumio

AU - Kato, Ineko

AU - Suzuki, Satoshi

AU - Sobajima, Hisanori

AU - Hara, Fujio

AU - Hashimoto, Takashi

AU - Togari, Hajime

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