High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

David Ellinghaus, Hansjörg Baurecht, Jorge Esparza-Gordillo, Elke Rodríguez, Anja Matanovic, Ingo Marenholz, Norbert Hübner, Heidi Schaarschmidt, Natalija Novak, Sven Michel, Laura Maintz, Thomas Werfel, Ulf Meyer-Hoffert, Melanie Hotze, Holger Prokisch, Katharina Heim, Christian Herder, Tomomitsu Hirota, Mayumi Tamari, Michiaki Kubo & 29 others Atsushi Takahashi, Yusuke Nakamura, Lam C. Tsoi, Philip Stuart, James T. Elder, Liangdan Sun, Xianbo Zuo, Sen Yang, Xuejun Zhang, Per Hoffmann, Markus M. Nöthen, Regina Fölster-Holst, Juliane Winkelmann, Thomas Illig, Bernhard O. Boehm, Richard H. Duerr, Carsten Büning, Stephan Brand, Jürgen Glas, Maeve A. McAleer, Caoimhe M. Fahy, Michael Kabesch, Sara Brown, W. H.Irwin McLean, Alan D. Irvine, Stefan Schreiber, Young Ae Lee, Andre Franke, Stephan Weidinger

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and identify additional susceptibility loci, we densely genotyped 2,425 German individuals with atopic dermatitis (cases) and 5,449 controls using the Immunochip array followed by replication in 7,196 cases and 15,480 controls from Germany, Ireland, Japan and China. We identified four new susceptibility loci for atopic dermatitis and replicated previous associations. This brings the number of atopic dermatitis risk loci reported in individuals of European ancestry to 11. We estimate that these susceptibility loci together account for 14.4% of the heritability for atopic dermatitis.

Original languageEnglish
Pages (from-to)808-812
Number of pages5
JournalNature Genetics
Volume45
Issue number7
DOIs
Publication statusPublished - 01-07-2013

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Atopic Dermatitis
Keratinocytes
Ireland
Skin Diseases
Germany
China
Japan
Skin

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Ellinghaus, D., Baurecht, H., Esparza-Gordillo, J., Rodríguez, E., Matanovic, A., Marenholz, I., ... Weidinger, S. (2013). High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nature Genetics, 45(7), 808-812. https://doi.org/10.1038/ng.2642
Ellinghaus, David ; Baurecht, Hansjörg ; Esparza-Gordillo, Jorge ; Rodríguez, Elke ; Matanovic, Anja ; Marenholz, Ingo ; Hübner, Norbert ; Schaarschmidt, Heidi ; Novak, Natalija ; Michel, Sven ; Maintz, Laura ; Werfel, Thomas ; Meyer-Hoffert, Ulf ; Hotze, Melanie ; Prokisch, Holger ; Heim, Katharina ; Herder, Christian ; Hirota, Tomomitsu ; Tamari, Mayumi ; Kubo, Michiaki ; Takahashi, Atsushi ; Nakamura, Yusuke ; Tsoi, Lam C. ; Stuart, Philip ; Elder, James T. ; Sun, Liangdan ; Zuo, Xianbo ; Yang, Sen ; Zhang, Xuejun ; Hoffmann, Per ; Nöthen, Markus M. ; Fölster-Holst, Regina ; Winkelmann, Juliane ; Illig, Thomas ; Boehm, Bernhard O. ; Duerr, Richard H. ; Büning, Carsten ; Brand, Stephan ; Glas, Jürgen ; McAleer, Maeve A. ; Fahy, Caoimhe M. ; Kabesch, Michael ; Brown, Sara ; McLean, W. H.Irwin ; Irvine, Alan D. ; Schreiber, Stefan ; Lee, Young Ae ; Franke, Andre ; Weidinger, Stephan. / High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. In: Nature Genetics. 2013 ; Vol. 45, No. 7. pp. 808-812.
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Ellinghaus, D, Baurecht, H, Esparza-Gordillo, J, Rodríguez, E, Matanovic, A, Marenholz, I, Hübner, N, Schaarschmidt, H, Novak, N, Michel, S, Maintz, L, Werfel, T, Meyer-Hoffert, U, Hotze, M, Prokisch, H, Heim, K, Herder, C, Hirota, T, Tamari, M, Kubo, M, Takahashi, A, Nakamura, Y, Tsoi, LC, Stuart, P, Elder, JT, Sun, L, Zuo, X, Yang, S, Zhang, X, Hoffmann, P, Nöthen, MM, Fölster-Holst, R, Winkelmann, J, Illig, T, Boehm, BO, Duerr, RH, Büning, C, Brand, S, Glas, J, McAleer, MA, Fahy, CM, Kabesch, M, Brown, S, McLean, WHI, Irvine, AD, Schreiber, S, Lee, YA, Franke, A & Weidinger, S 2013, 'High-density genotyping study identifies four new susceptibility loci for atopic dermatitis', Nature Genetics, vol. 45, no. 7, pp. 808-812. https://doi.org/10.1038/ng.2642

High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. / Ellinghaus, David; Baurecht, Hansjörg; Esparza-Gordillo, Jorge; Rodríguez, Elke; Matanovic, Anja; Marenholz, Ingo; Hübner, Norbert; Schaarschmidt, Heidi; Novak, Natalija; Michel, Sven; Maintz, Laura; Werfel, Thomas; Meyer-Hoffert, Ulf; Hotze, Melanie; Prokisch, Holger; Heim, Katharina; Herder, Christian; Hirota, Tomomitsu; Tamari, Mayumi; Kubo, Michiaki; Takahashi, Atsushi; Nakamura, Yusuke; Tsoi, Lam C.; Stuart, Philip; Elder, James T.; Sun, Liangdan; Zuo, Xianbo; Yang, Sen; Zhang, Xuejun; Hoffmann, Per; Nöthen, Markus M.; Fölster-Holst, Regina; Winkelmann, Juliane; Illig, Thomas; Boehm, Bernhard O.; Duerr, Richard H.; Büning, Carsten; Brand, Stephan; Glas, Jürgen; McAleer, Maeve A.; Fahy, Caoimhe M.; Kabesch, Michael; Brown, Sara; McLean, W. H.Irwin; Irvine, Alan D.; Schreiber, Stefan; Lee, Young Ae; Franke, Andre; Weidinger, Stephan.

In: Nature Genetics, Vol. 45, No. 7, 01.07.2013, p. 808-812.

Research output: Contribution to journalArticle

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T1 - High-density genotyping study identifies four new susceptibility loci for atopic dermatitis

AU - Ellinghaus, David

AU - Baurecht, Hansjörg

AU - Esparza-Gordillo, Jorge

AU - Rodríguez, Elke

AU - Matanovic, Anja

AU - Marenholz, Ingo

AU - Hübner, Norbert

AU - Schaarschmidt, Heidi

AU - Novak, Natalija

AU - Michel, Sven

AU - Maintz, Laura

AU - Werfel, Thomas

AU - Meyer-Hoffert, Ulf

AU - Hotze, Melanie

AU - Prokisch, Holger

AU - Heim, Katharina

AU - Herder, Christian

AU - Hirota, Tomomitsu

AU - Tamari, Mayumi

AU - Kubo, Michiaki

AU - Takahashi, Atsushi

AU - Nakamura, Yusuke

AU - Tsoi, Lam C.

AU - Stuart, Philip

AU - Elder, James T.

AU - Sun, Liangdan

AU - Zuo, Xianbo

AU - Yang, Sen

AU - Zhang, Xuejun

AU - Hoffmann, Per

AU - Nöthen, Markus M.

AU - Fölster-Holst, Regina

AU - Winkelmann, Juliane

AU - Illig, Thomas

AU - Boehm, Bernhard O.

AU - Duerr, Richard H.

AU - Büning, Carsten

AU - Brand, Stephan

AU - Glas, Jürgen

AU - McAleer, Maeve A.

AU - Fahy, Caoimhe M.

AU - Kabesch, Michael

AU - Brown, Sara

AU - McLean, W. H.Irwin

AU - Irvine, Alan D.

AU - Schreiber, Stefan

AU - Lee, Young Ae

AU - Franke, Andre

AU - Weidinger, Stephan

PY - 2013/7/1

Y1 - 2013/7/1

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Ellinghaus D, Baurecht H, Esparza-Gordillo J, Rodríguez E, Matanovic A, Marenholz I et al. High-density genotyping study identifies four new susceptibility loci for atopic dermatitis. Nature Genetics. 2013 Jul 1;45(7):808-812. https://doi.org/10.1038/ng.2642