High dose chemotherapy with autologous bone marrow transplantation for limited small cell lung cancer

Fumio Nomura, Kaoru Shimokata, Hiroshi Saito, Atsushi Watanabe, Hideo Saka, Shuzo Sakai, Yoshihisa Kodera, Hidehiko Saito

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

In 1980 we initiated a pilot study of high dose chemotherapy intensified with autologous bone marrow transplantation (ABMT) for seven patients with limited small cell lung cancer. Six patients were given the ABMT initially while one male patient received the ABMT late to intensify three courses of induction therapy. He further received radiotherapy and underwent a left pneumonectomy and adoptive immunotherapy, because the presence of residual tumor cells, and has maintained desease-free survival for over 117 weeks. Among the first six patients there were two with complete responses, two with partial responses and one who experienced no change, a total response rate of 80%. One patient died of cardiac tamponade at day 7 and could not be evaluated. The median survival time of 41 (range 34-108) weeks was not encouraging. In conclusion: an increased drug dose with ABMT to intensify the chemotherapy provided disappointing results both when the ABMT was used initially and when it was given late, after induction chemotherapy.

Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalJapanese journal of clinical oncology
Volume20
Issue number1
Publication statusPublished - 03-1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint

Dive into the research topics of 'High dose chemotherapy with autologous bone marrow transplantation for limited small cell lung cancer'. Together they form a unique fingerprint.

Cite this