High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial

Ken Takase; Akiko Kada; Hiromi Iwasaki; Isao Yoshida; Morio Sawamura; Nobuyuki Yoshio; Shinichiro Yoshida; Hiroatsu Iida; Maki Otsuka; Toshiro Takafuta; Yuko Ogata; Youko Suehiro; Yukio Hirabayashi; Terutoshi Hishita; Chikamasa Yoshida; Takuo Ito; Michihiro Hidaka; Ikuyo Tsutsumi; Akiko M. Saito; Hirokazu Nagai

High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial

Ken Takase, Akiko Kada, Hiromi Iwasaki, Isao Yoshida, Morio Sawamura, Nobuyuki Yoshio, Shinichiro Yoshida, Hiroatsu Iida, Maki Otsuka, Toshiro Takafuta, Yuko Ogata, Youko Suehiro, Yukio Hirabayashi, Terutoshi Hishita, Chikamasa Yoshida, Takuo Ito, Michihiro Hidaka, Ikuyo Tsutsumi, Akiko M. Saito, Hirokazu Nagai

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of < 20, 000 /μL, or with < 50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy. The results of this investigation of the effectiveness and safety of this regimen will be essential for the establishment of standard therapy for ITP.

Original language	English
Pages (from-to)	197-201
Number of pages	5
Journal	Acta Medica Okayama
Volume	72
Issue number	2
Publication status	Published - 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Cite this

Takase, K., Kada, A., Iwasaki, H., Yoshida, I., Sawamura, M., Yoshio, N., Yoshida, S., Iida, H., Otsuka, M., Takafuta, T., Ogata, Y., Suehiro, Y., Hirabayashi, Y., Hishita, T., Yoshida, C., Ito, T., Hidaka, M., Tsutsumi, I., Saito, A. M., & Nagai, H. (2018). High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial. Acta Medica Okayama, 72(2), 197-201.

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title = "High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial",

abstract = "Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of < 20, 000 /μL, or with < 50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy. The results of this investigation of the effectiveness and safety of this regimen will be essential for the establishment of standard therapy for ITP.",

author = "Ken Takase and Akiko Kada and Hiromi Iwasaki and Isao Yoshida and Morio Sawamura and Nobuyuki Yoshio and Shinichiro Yoshida and Hiroatsu Iida and Maki Otsuka and Toshiro Takafuta and Yuko Ogata and Youko Suehiro and Yukio Hirabayashi and Terutoshi Hishita and Chikamasa Yoshida and Takuo Ito and Michihiro Hidaka and Ikuyo Tsutsumi and Saito, {Akiko M.} and Hirokazu Nagai",

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year = "2018",

language = "English",

volume = "72",

pages = "197--201",

journal = "Acta Medica Okayama",

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Takase, K, Kada, A, Iwasaki, H, Yoshida, I, Sawamura, M, Yoshio, N, Yoshida, S, Iida, H, Otsuka, M, Takafuta, T, Ogata, Y, Suehiro, Y, Hirabayashi, Y, Hishita, T, Yoshida, C, Ito, T, Hidaka, M, Tsutsumi, I, Saito, AM & Nagai, H 2018, 'High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial', Acta Medica Okayama, vol. 72, no. 2, pp. 197-201.

TY - JOUR

T1 - High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura

T2 - Protocol for a multicenter, open-label, single arm trial

AU - Takase, Ken

AU - Kada, Akiko

AU - Iwasaki, Hiromi

AU - Yoshida, Isao

AU - Sawamura, Morio

AU - Yoshio, Nobuyuki

AU - Yoshida, Shinichiro

AU - Iida, Hiroatsu

AU - Otsuka, Maki

AU - Takafuta, Toshiro

AU - Ogata, Yuko

AU - Suehiro, Youko

AU - Hirabayashi, Yukio

AU - Hishita, Terutoshi

AU - Yoshida, Chikamasa

AU - Ito, Takuo

AU - Hidaka, Michihiro

AU - Tsutsumi, Ikuyo

AU - Saito, Akiko M.

AU - Nagai, Hirokazu

PY - 2018

Y1 - 2018

N2 - Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of < 20, 000 /μL, or with < 50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy. The results of this investigation of the effectiveness and safety of this regimen will be essential for the establishment of standard therapy for ITP.

AB - Standard therapy for idiopathic thrombocytopenic purpura (ITP) has not been established. We are conducting a multicenter, prospective trial to determine the efficacy and safety of short-term, high-dose dexamethasone therapy in ITP patients aged 18-80 years with platelet counts of < 20, 000 /μL, or with < 50, 000/ μL and bleeding symptoms. The primary endpoints of this trial are the proportion of responses (complete plus partial response) on day 180 (day 46+180) after the completion of the 46-day high-dose dexamethasone therapy. The results of this investigation of the effectiveness and safety of this regimen will be essential for the establishment of standard therapy for ITP.

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ER -

High-dose dexamethasone therapy as the initial treatment for idiopathic thrombocytopenic purpura: Protocol for a multicenter, open-label, single arm trial

Abstract

All Science Journal Classification (ASJC) codes

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