High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats

Hai Quyen Tran, Yoon Hee Chung, Eun Joo Shin, Won Ki Kim, Jae Chul Lee, Ji Hoon Jeong, Myung Bok Wie, Choon Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung Chun Kim

Research output: Contribution to journalArticle

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Abstract

Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalJournal of Pharmacological Sciences
Volume132
Issue number2
DOIs
Publication statusPublished - 01-10-2016

Fingerprint

Dextromethorphan
Hippocampus
Dizocilpine Maleate
Antitussive Agents
Imines
Naloxone
Toxicology

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Tran, H. Q., Chung, Y. H., Shin, E. J., Kim, W. K., Lee, J. C., Jeong, J. H., ... Kim, H. C. (2016). High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. Journal of Pharmacological Sciences, 132(2), 166-170. https://doi.org/10.1016/j.jphs.2016.10.001
Tran, Hai Quyen ; Chung, Yoon Hee ; Shin, Eun Joo ; Kim, Won Ki ; Lee, Jae Chul ; Jeong, Ji Hoon ; Wie, Myung Bok ; Jang, Choon Gon ; Yamada, Kiyofumi ; Nabeshima, Toshitaka ; Kim, Hyoung Chun. / High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. In: Journal of Pharmacological Sciences. 2016 ; Vol. 132, No. 2. pp. 166-170.
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abstract = "Dextromethorphan (DM) administered at supra-antitussive doses produce psychotoxic and neurotoxic effects in humans. We administered DM (80 mg/kg) to rats intraperitoneally to determine the ultrastructural change induced by DM, because intraperitoneal route is sensitive for the behavioral responses. Treatment with DM resulted in mitochondrial dysfunction and formation of myelinoid bodies in the hippocampus. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] attenuated DM-induced cytosolic oxidative burdens. However, neither MK-801 nor naloxone affected DM-induced mitochondrial dysfunction and formation of myelinoid bodies, indicating that the neurotoxic mechanism needs to be further elucidated. Therefore, the spectrum of toxicological effects associated with DM need to be reassessed.",
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Tran, HQ, Chung, YH, Shin, EJ, Kim, WK, Lee, JC, Jeong, JH, Wie, MB, Jang, CG, Yamada, K, Nabeshima, T & Kim, HC 2016, 'High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats', Journal of Pharmacological Sciences, vol. 132, no. 2, pp. 166-170. https://doi.org/10.1016/j.jphs.2016.10.001

High-dose dextromethorphan produces myelinoid bodies in the hippocampus of rats. / Tran, Hai Quyen; Chung, Yoon Hee; Shin, Eun Joo; Kim, Won Ki; Lee, Jae Chul; Jeong, Ji Hoon; Wie, Myung Bok; Jang, Choon Gon; Yamada, Kiyofumi; Nabeshima, Toshitaka; Kim, Hyoung Chun.

In: Journal of Pharmacological Sciences, Vol. 132, No. 2, 01.10.2016, p. 166-170.

Research output: Contribution to journalArticle

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AU - Tran, Hai Quyen

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