High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

Yan Guo, Adam D. Tomich, Christi L. McElheny, Vaughn S. Cooper, Amelia Tait-Kamradt, Minggui Wang, Fupin Hu, Louis B. Rice, Nicolas Sluis-Cremer, Yohei Doi

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Abstract

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

Original languageEnglish
Pages (from-to)1902-1904
Number of pages3
JournalEmerging Infectious Diseases
Volume23
Issue number11
DOIs
Publication statusPublished - 11-2017

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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    Guo, Y., Tomich, A. D., McElheny, C. L., Cooper, V. S., Tait-Kamradt, A., Wang, M., Hu, F., Rice, L. B., Sluis-Cremer, N., & Doi, Y. (2017). High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium. Emerging Infectious Diseases, 23(11), 1902-1904. https://doi.org/10.3201/eid2311.171130