TY - JOUR
T1 - High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium
AU - Guo, Yan
AU - Tomich, Adam D.
AU - McElheny, Christi L.
AU - Cooper, Vaughn S.
AU - Tait-Kamradt, Amelia
AU - Wang, Minggui
AU - Hu, Fupin
AU - Rice, Louis B.
AU - Sluis-Cremer, Nicolas
AU - Doi, Yohei
N1 - Publisher Copyright:
© 2017, Centers for Disease Control and Prevention (CDC). All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.
AB - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.
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U2 - 10.3201/eid2311.171130
DO - 10.3201/eid2311.171130
M3 - Article
C2 - 29048285
AN - SCOPUS:85032028745
SN - 1080-6040
VL - 23
SP - 1902
EP - 1904
JO - Emerging Infectious Diseases
JF - Emerging Infectious Diseases
IS - 11
ER -
