High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

Yan Guo; Adam D. Tomich; Christi L. McElheny; Vaughn S. Cooper; Amelia Tait-Kamradt; Minggui Wang; Fupin Hu; Louis B. Rice; Nicolas Sluis-Cremer; Yohei Doi

doi:10.3201/eid2311.171130

High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

Yan Guo
, Adam D. Tomich
, Christi L. McElheny
, Vaughn S. Cooper
, Amelia Tait-Kamradt
, Minggui Wang
, Fupin Hu
, Louis B. Rice
, Nicolas Sluis-Cremer
, Yohei Doi

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

Original language	English
Pages (from-to)	1902-1904
Number of pages	3
Journal	Emerging Infectious Diseases
Volume	23
Issue number	11
DOIs	https://doi.org/10.3201/eid2311.171130
Publication status	Published - 11-2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Epidemiology
Microbiology (medical)
Infectious Diseases

Access to Document

10.3201/eid2311.171130

Cite this

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title = "High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium",

abstract = "Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.",

author = "Yan Guo and Tomich, \{Adam D.\} and McElheny, \{Christi L.\} and Cooper, \{Vaughn S.\} and Amelia Tait-Kamradt and Minggui Wang and Fupin Hu and Rice, \{Louis B.\} and Nicolas Sluis-Cremer and Yohei Doi",

year = "2017",

month = nov,

doi = "10.3201/eid2311.171130",

language = "English",

volume = "23",

pages = "1902--1904",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

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}

TY - JOUR

T1 - High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

AU - Guo, Yan

AU - Tomich, Adam D.

AU - McElheny, Christi L.

AU - Cooper, Vaughn S.

AU - Tait-Kamradt, Amelia

AU - Wang, Minggui

AU - Hu, Fupin

AU - Rice, Louis B.

AU - Sluis-Cremer, Nicolas

AU - Doi, Yohei

PY - 2017/11

Y1 - 2017/11

N2 - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

AB - Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 µg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC ≥4-fold and rendered this drug inactive in biochemical assays.

UR - https://www.scopus.com/pages/publications/85032028745

UR - https://www.scopus.com/pages/publications/85032028745#tab=citedBy

U2 - 10.3201/eid2311.171130

DO - 10.3201/eid2311.171130

M3 - Article

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AN - SCOPUS:85032028745

SN - 1080-6040

VL - 23

SP - 1902

EP - 1904

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 11

ER -

High-level fosfomycin resistance in vancomycin-resistant Enterococcus faecium

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

Access to Document

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