TY - JOUR
T1 - High levels of boron promote anchorage-independent growth of nontumorigenic cells
AU - Xu, Huadong
AU - Hashimoto, Kazunori
AU - Maeda, Masao
AU - Azimi, Mohammad Daud
AU - Fayaz, Said Hafizullah
AU - Chen, Wei
AU - Hamajima, Nobuyuki
AU - Kato, Masashi
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.
AB - WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.
KW - Boron
KW - Tumorigenic pathway
KW - Tumorigenic risk
KW - Well drinking water
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U2 - 10.1016/j.envpol.2020.115094
DO - 10.1016/j.envpol.2020.115094
M3 - Article
C2 - 32659568
AN - SCOPUS:85087732083
SN - 0269-7491
VL - 266
JO - Environmental Pollution
JF - Environmental Pollution
M1 - 115094
ER -
