High levels of boron promote anchorage-independent growth of nontumorigenic cells

Huadong Xu, Kazunori Hashimoto, Masao Maeda, Mohammad Daud Azimi, Said Hafizullah Fayaz, Wei Chen, Nobuyuki Hamajima, Masashi Kato

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.

Original languageEnglish
Article number115094
JournalEnvironmental Pollution
Publication statusPublished - 11-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis


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