High levels of boron promote anchorage-independent growth of nontumorigenic cells

Huadong Xu, Kazunori Hashimoto, Masao Maeda, Mohammad Daud Azimi, Said Hafizullah Fayaz, Wei Chen, Nobuyuki Hamajima, Masashi Kato

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Abstract

WHO has presented a health-based guideline value for boron in drinking water. That fact indicates that a high level of boron is toxic for humans. However, there is no direct evidence of boron-mediated malignant transformation. In this study, human lung epithelial nontumorigenic BEAS-2B cells and tumorigenic A549 cells were used to investigate the tumorigenic toxicity of boron in vitro. Anchorage-independent growth, a hallmark of malignant transformation, was increased by boron at concentrations of 50, 250 and 500 μM in BEAS-2B cells, though the same concentrations of boron had no influence on anchorage-independent growth of A549 cells. Moreover, boron at concentrations of 250 and 500 μM activated the c-SRC/PI3K/AKT pathway of BEAS-2B cells. The results of our in vitro study suggest that exposure to high levels of boron promotes transforming activity of nontumorigenic cells.

Original languageEnglish
Article number115094
JournalEnvironmental Pollution
Volume266
DOIs
Publication statusPublished - 11-2020

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

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    Xu, H., Hashimoto, K., Maeda, M., Azimi, M. D., Fayaz, S. H., Chen, W., Hamajima, N., & Kato, M. (2020). High levels of boron promote anchorage-independent growth of nontumorigenic cells. Environmental Pollution, 266, [115094]. https://doi.org/10.1016/j.envpol.2020.115094