TY - JOUR
T1 - High-mobility-group box chromosomal protein 1 as a new target for modulating stress response
AU - Suda, Koichi
AU - Takeuchi, Hiroya
AU - Ishizaka, Akitoshi
AU - Kitagawa, Yuko
PY - 2010/7
Y1 - 2010/7
N2 - Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.
AB - Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.
KW - Alarmin
KW - High-mobility-group box chromosomal protein 1
KW - Multiple organ dysfunction syndrome
KW - Pathogen-associated molecular pattern
KW - Stress response
KW - Systemic inflammatory response syndrome
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U2 - 10.1007/s00595-009-4232-1
DO - 10.1007/s00595-009-4232-1
M3 - Review article
C2 - 20582508
AN - SCOPUS:77955636468
SN - 0941-1291
VL - 40
SP - 592
EP - 601
JO - Surgery Today
JF - Surgery Today
IS - 7
ER -