High-mobility-group box chromosomal protein 1 as a new target for modulating stress response

Koichi Suda; Hiroya Takeuchi; Akitoshi Ishizaka; Yuko Kitagawa

doi:10.1007/s00595-009-4232-1

High-mobility-group box chromosomal protein 1 as a new target for modulating stress response

Koichi Suda, Hiroya Takeuchi, Akitoshi Ishizaka, Yuko Kitagawa

Research output: Contribution to journal › Review article › peer-review

11 Citations (Scopus)

Abstract

Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.

Original language	English
Pages (from-to)	592-601
Number of pages	10
Journal	Surgery Today
Volume	40
Issue number	7
DOIs	https://doi.org/10.1007/s00595-009-4232-1
Publication status	Published - 01-07-2010
Externally published	Yes

All Science Journal Classification (ASJC) codes

Surgery

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abstract = "Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.",

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AB - Major surgical procedures induce a systemic inflammatory response syndrome (SIRS) characterized by the overproduction of proinflammatory cytokines, which induces excessive stress and may trigger postoperative complications. This has prompted the hypothesis that drugs which relieve SIRS might improve the postoperative course of major surgery. One of the most promising targets for these drugs is high-mobility-group box chromosomal protein 1 (HMGB1). In 1999, HMGB1 was found to be a key late mediator of sepsis. It is now known to be associated with various kinds of acute and chronic inflammation, and is recognized as one of the most important danger signals in stress response. In this article, we present the latest information about HMGB1 and discuss its promise as a novel target for modulating stress response.

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