High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Ryan K. Shields, Eun J. Kwak, Brian A. Potoski, Yohei Doi, Jennifer M. Adams-Haduch, Fernanda P. Silviera, Yoshiya Toyoda, Joseph M. Pilewski, Maria Crespo, A. William Pasculle, Cornelius J. Clancy, M. Hong Nguyen

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume70
Issue number2
DOIs
Publication statusPublished - 01-06-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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