High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii: Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen

Ryan K. Shields, Eun J. Kwak, Brian A. Potoski, Yohei Doi, Jennifer M. Adams-Haduch, Fernanda P. Silviera, Yoshiya Toyoda, Joseph M. Pilewski, Maria Crespo, A. William Pasculle, Cornelius J. Clancy, M. Hong Nguyen

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Extensively drug-resistant (XDR) Acinetobacter baumannii infections caused 91% (10/11) mortality in transplant recipients. Isolates were colistin-susceptible initially, but susceptibility decreased during therapy in 40% (4/10). We tested antibiotic combinations against XDR Acinetobacter in vitro and demonstrated positive interactions for carbapenem-colistin. Subsequently, 80% (4/5) of transplant patients were treated successfully with carbepenem-colistin regimens.

Original languageEnglish
Pages (from-to)246-252
Number of pages7
JournalDiagnostic Microbiology and Infectious Disease
Volume70
Issue number2
DOIs
Publication statusPublished - 01-06-2011
Externally publishedYes

Fingerprint

Colistin
Acinetobacter baumannii
Carbapenems
Anti-Bacterial Agents
Transplants
Mortality
Acinetobacter Infections
Pharmaceutical Preparations
Acinetobacter
Therapeutics
In Vitro Techniques
Transplant Recipients

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Shields, Ryan K. ; Kwak, Eun J. ; Potoski, Brian A. ; Doi, Yohei ; Adams-Haduch, Jennifer M. ; Silviera, Fernanda P. ; Toyoda, Yoshiya ; Pilewski, Joseph M. ; Crespo, Maria ; Pasculle, A. William ; Clancy, Cornelius J. ; Nguyen, M. Hong. / High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii : Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. In: Diagnostic Microbiology and Infectious Disease. 2011 ; Vol. 70, No. 2. pp. 246-252.
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High mortality rates among solid organ transplant recipients infected with extensively drug-resistant Acinetobacter baumannii : Using in vitro antibiotic combination testing to identify the combination of a carbapenem and colistin as an effective treatment regimen. / Shields, Ryan K.; Kwak, Eun J.; Potoski, Brian A.; Doi, Yohei; Adams-Haduch, Jennifer M.; Silviera, Fernanda P.; Toyoda, Yoshiya; Pilewski, Joseph M.; Crespo, Maria; Pasculle, A. William; Clancy, Cornelius J.; Nguyen, M. Hong.

In: Diagnostic Microbiology and Infectious Disease, Vol. 70, No. 2, 01.06.2011, p. 246-252.

Research output: Contribution to journalArticle

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