TY - JOUR
T1 - High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing
AU - Yamamura, Keiko
AU - Yamada, Jun Ichiro
AU - Yotsuyanagi, Toshihisa
PY - 1985
Y1 - 1985
N2 - High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E1 (PGE1, PGE1-α-cyclodextrin (PGE1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE1, PGE1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.
AB - High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E1 (PGE1, PGE1-α-cyclodextrin (PGE1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE1, PGE1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.
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U2 - 10.1016/0021-9673(85)80044-3
DO - 10.1016/0021-9673(85)80044-3
M3 - Article
C2 - 3932443
AN - SCOPUS:0022360530
SN - 0021-9673
VL - 331
SP - 383
EP - 388
JO - Journal of Chromatography A
JF - Journal of Chromatography A
IS - C
ER -