High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing

Keiko Yamamura; Jun Ichiro Yamada; Toshihisa Yotsuyanagi

doi:10.1016/0021-9673(85)80044-3

High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing

Keiko Yamamura
, Jun Ichiro Yamada
, Toshihisa Yotsuyanagi

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E₁ (PGE₁, PGE₁-α-cyclodextrin (PGE₁,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE₁, PGE₁-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.

Original language	English
Pages (from-to)	383-388
Number of pages	6
Journal	Journal of Chromatography A
Volume	331
Issue number	C
DOIs	https://doi.org/10.1016/0021-9673(85)80044-3
Publication status	Published - 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Biochemistry
Organic Chemistry

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10.1016/0021-9673(85)80044-3

Cite this

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title = "High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing",

abstract = "High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E1 (PGE1, PGE1-α-cyclodextrin (PGE1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3\%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100\%. The stabilities of PGE1, PGE1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.",

author = "Keiko Yamamura and Yamada, \{Jun Ichiro\} and Toshihisa Yotsuyanagi",

year = "1985",

doi = "10.1016/0021-9673(85)80044-3",

language = "English",

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T1 - High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing

AU - Yamamura, Keiko

AU - Yamada, Jun Ichiro

AU - Yotsuyanagi, Toshihisa

PY - 1985

Y1 - 1985

N2 - High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E1 (PGE1, PGE1-α-cyclodextrin (PGE1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE1, PGE1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.

AB - High-performance liquid chromatographic determinations of gabexate mesilate (FOY) prostaglandin E1 (PGE1, PGE1-α-cyclodextrin (PGE1,-CD), prednisolone (PD) and butyl flufenamate (BF) incorporated in gel ointment were investigated. The gel ointment is composed of a carboxy vinyl polymer (1.3%, w/w) and a large amount of an aqueous organic solvent. A methanol extraction system offered simultaneous advantages of the removal of the polymer and the recovery of active ingredients from the gel phase. The recoveries of the drugs were 100%. The stabilities of PGE1, PGE1-CD, FOY, PD and BF incorporated in gel ointment, stored at 5, 25 and 40°C for up to 90 days, were investigated.

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DO - 10.1016/0021-9673(85)80044-3

M3 - Article

C2 - 3932443

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VL - 331

SP - 383

EP - 388

JO - Journal of Chromatography A

JF - Journal of Chromatography A

IS - C

ER -

High-performance liquid chromatographic assay of anti-inflammatory drugs incorporated in gel ointments Separation and stability testing

Abstract

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