High postnatal oxidative stress in neonatal cystic periventricular leukomalacia

Hiroki Kakita, Mohamed Hamed Hussein, Yasumasa Yamada, Hayato Henmi, Shin Kato, Satoru Kobayashi, Tetsuya Ito, Ineko Kato, Sumio Fukuda, Satoshi Suzuki, Hajime Togari

Research output: Contribution to journalArticle

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Abstract

Oxidative stress plays an important role in cystic periventricular leukomalacia (PVL). We performed a case-control study of preterm infants delivered at <35 weeks of gestation between January 2003 and December 2006. Patients were stratified into three groups, according to age at which cysts were initially identified: ≤10 days old (early cystic PVL; n = 10), >10 days old (late cystic PVL; n = 12); and no cystic PVL (controls; n = 22). Serum total hydroperoxide, biological antioxidant potential and oxidative stress index (calculated as total hydroperoxide/biological antioxidant potential) were measured within 3 h after birth. Frequencies of preterm rupture of membrane and chorioamnionitis were significant higher in early cystic PVL than in late cystic PVL or controls. Duration of oxygen treatment and mechanical ventilation and frequency of apnea were significantly higher in late cystic PVL than in controls or early cystic PVL. Serum total hydroperoxide levels and oxidative stress index were significantly higher in early cystic PVL than in late cystic PVL or controls (p < 0.05, respectively). Postnatal duration until cyst identification displayed a significant negative correlation with oxidative stress index and total hydroperoxide level (r = -0.497, p < 0.05; r = -0.50, p < 0.05, respectively). These findings suggest that early onset of cystic PVL might be due to either antenatal or intrapartum factors, but late onset might be due to postnatal factors. In the pathophysiology and therapy of cystic PVL, oxidative stress and onset timing appear crucial. This is the first study to reveal that neonates experiencing much more oxidative stress at birth show earlier onset of cystic PVL. Crown

Original languageEnglish
Pages (from-to)641-648
Number of pages8
JournalBrain and Development
Volume31
Issue number9
DOIs
Publication statusPublished - 01-10-2009
Externally publishedYes

Fingerprint

Periventricular Leukomalacia
Oxidative Stress
Hydrogen Peroxide
Antioxidants
Parturition
Chorioamnionitis
Apnea
Crowns
Serum
Artificial Respiration
Premature Infants
Case-Control Studies
Cysts
Rupture

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kakita, H., Hussein, M. H., Yamada, Y., Henmi, H., Kato, S., Kobayashi, S., ... Togari, H. (2009). High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. Brain and Development, 31(9), 641-648. https://doi.org/10.1016/j.braindev.2008.10.008
Kakita, Hiroki ; Hussein, Mohamed Hamed ; Yamada, Yasumasa ; Henmi, Hayato ; Kato, Shin ; Kobayashi, Satoru ; Ito, Tetsuya ; Kato, Ineko ; Fukuda, Sumio ; Suzuki, Satoshi ; Togari, Hajime. / High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. In: Brain and Development. 2009 ; Vol. 31, No. 9. pp. 641-648.
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Kakita, H, Hussein, MH, Yamada, Y, Henmi, H, Kato, S, Kobayashi, S, Ito, T, Kato, I, Fukuda, S, Suzuki, S & Togari, H 2009, 'High postnatal oxidative stress in neonatal cystic periventricular leukomalacia', Brain and Development, vol. 31, no. 9, pp. 641-648. https://doi.org/10.1016/j.braindev.2008.10.008

High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. / Kakita, Hiroki; Hussein, Mohamed Hamed; Yamada, Yasumasa; Henmi, Hayato; Kato, Shin; Kobayashi, Satoru; Ito, Tetsuya; Kato, Ineko; Fukuda, Sumio; Suzuki, Satoshi; Togari, Hajime.

In: Brain and Development, Vol. 31, No. 9, 01.10.2009, p. 641-648.

Research output: Contribution to journalArticle

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AU - Kakita, Hiroki

AU - Hussein, Mohamed Hamed

AU - Yamada, Yasumasa

AU - Henmi, Hayato

AU - Kato, Shin

AU - Kobayashi, Satoru

AU - Ito, Tetsuya

AU - Kato, Ineko

AU - Fukuda, Sumio

AU - Suzuki, Satoshi

AU - Togari, Hajime

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N2 - Oxidative stress plays an important role in cystic periventricular leukomalacia (PVL). We performed a case-control study of preterm infants delivered at <35 weeks of gestation between January 2003 and December 2006. Patients were stratified into three groups, according to age at which cysts were initially identified: ≤10 days old (early cystic PVL; n = 10), >10 days old (late cystic PVL; n = 12); and no cystic PVL (controls; n = 22). Serum total hydroperoxide, biological antioxidant potential and oxidative stress index (calculated as total hydroperoxide/biological antioxidant potential) were measured within 3 h after birth. Frequencies of preterm rupture of membrane and chorioamnionitis were significant higher in early cystic PVL than in late cystic PVL or controls. Duration of oxygen treatment and mechanical ventilation and frequency of apnea were significantly higher in late cystic PVL than in controls or early cystic PVL. Serum total hydroperoxide levels and oxidative stress index were significantly higher in early cystic PVL than in late cystic PVL or controls (p < 0.05, respectively). Postnatal duration until cyst identification displayed a significant negative correlation with oxidative stress index and total hydroperoxide level (r = -0.497, p < 0.05; r = -0.50, p < 0.05, respectively). These findings suggest that early onset of cystic PVL might be due to either antenatal or intrapartum factors, but late onset might be due to postnatal factors. In the pathophysiology and therapy of cystic PVL, oxidative stress and onset timing appear crucial. This is the first study to reveal that neonates experiencing much more oxidative stress at birth show earlier onset of cystic PVL. Crown

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Kakita H, Hussein MH, Yamada Y, Henmi H, Kato S, Kobayashi S et al. High postnatal oxidative stress in neonatal cystic periventricular leukomalacia. Brain and Development. 2009 Oct 1;31(9):641-648. https://doi.org/10.1016/j.braindev.2008.10.008