High prevalence and phylogenetic analysis of TT-virus infection in Mongolia

Hideaki Kato, Masashi Mizokami, Tatsunori Nakano, Yutaka Kondo, Bumbein Dashnyam, Tsendsuren Oyunsuren, Ryuzo Ueda

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A novel DNA virus, TT-virus (TTV), was isolated from a post-transfusion hepatitis patient in Japan. The prevalence of TTV infection was investigated among patients with chronic liver disease and normal alanine aminotransferase (ALT) volunteers as controls in Mongolia. Polymerase chain reaction (PCR) was employed to detect TTV DNA using specific primers derived from open reading frame 1 (ORF1) of the TTV genome. Nucleotide sequences of samples positive for TTV DNA were determined. The sequences were analyzed by a molecular evolutionary method. Fifty (60.2%) hepatitis patients and 12 (42.9%) volunteers were positive for TTV DNA. The serum ALT levels did not differ significantly between patients with single TTV infection and without TTV, HBV and HCV infection. Similarly, the serum ALT levels did not differ significantly between controls with and without TTV infection. Dual infection of TTV with either HBV or HCV did not affect the ALT levels of hepatitis patients. The molecular evolutionary tree showed that TTV was a heterogeneous virus and all strains could be divided into three genotypes in Mongolia. A new genotype was identified that was distinct from those previously reported. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)171-179
Number of pages9
JournalVirus Research
Volume60
Issue number2
DOIs
Publication statusPublished - 04-1999

All Science Journal Classification (ASJC) codes

  • Cancer Research
  • Virology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'High prevalence and phylogenetic analysis of TT-virus infection in Mongolia'. Together they form a unique fingerprint.

  • Cite this

    Kato, H., Mizokami, M., Nakano, T., Kondo, Y., Dashnyam, B., Oyunsuren, T., & Ueda, R. (1999). High prevalence and phylogenetic analysis of TT-virus infection in Mongolia. Virus Research, 60(2), 171-179. https://doi.org/10.1016/S0168-1702(99)00016-7