High Prevalence of Orthostatic Dysregulation among Circadian Rhythm Disorder Patients

Akiko Tsuchiya, Tsuyoshi Kitajima, Satoe Tomita, Yuichi Esaki, Marina Hirose, Nakao Iwata

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Study Objectives: Patients with circadian rhythm sleep disorders (CRSDs) often have coincidence of orthostatic dysregulation (OD). Both disorders have many common clinical features. However, the prevalence of OD in patients with CRSD has not been examined. Methods: Thirty-eight patients with CRSD with either delayed sleep phase disorder or free-running disorder were tested for OD using the new orthostatic test, which was originally established by Tanaka et al. (< 20 years) and the Schellong test, i.e., the active standing test (≥ 20 years). Results: The overall prevalence of OD in patients with CRSD was 57.9% (22/38), and prevalence of OD was 70% in patients under 20 years of age (14/20). These rates exceed the previously reported values in adolescents aged 14-15 years (15%), regarded as the age with highest OD prevalence. Prevalence was not significantly associated with CRSD severity and medications used. Conclusions: We observed a high prevalence of OD in patients with CRSD, suggesting some relationship between CRSD and OD. Large-scale case-control studies are warranted to investigate the underlying mechanisms for this comorbidity.

Original languageEnglish
Pages (from-to)1471-1476
Number of pages6
JournalJournal of Clinical Sleep Medicine
Volume12
Issue number11
DOIs
Publication statusPublished - 01-01-2016

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

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