High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons

Taichiro Takemura, Masahiro Yamashita, Makoto K. Shimada, Sadayuki Ohkura, Takayoshi Shotake, Mikio Ikeda, Tomoyuki Miura, Masanori Hayami

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37 Citations (Scopus)

Abstract

Simian T-cell leukemia viruses (STLVs) are the simian counterparts of human T-cell leukemia viruses (HTLVs). A novel, divergent type of STLV (STLV-L) from captive baboons was reported in 1994, but its natural prevalence remained unclear. We investigated the prevalence of STLV-L in 519 blood samples from wild-living nonhuman primates in Ethiopia. Seropositive monkeys having cross-reactive antibodies against HTLV were found among 22 out of 40 hamadryas baboons, 8 of 96 anubis baboons, 24 of 50 baboons that are hybrids between hamadryas and anubis baboons, and 41 of 177 grivet monkeys, but not in 156 gelada baboons. A Western blotting assay showed that sera obtained from seropositive hamadryas and hybrid baboons exhibited STLV-L-like reactivity. A PCR assay successfully amplified STLV sequences, which were subsequently sequenced and confirmed as being closely related to STLV-L. Surprisingly, further PCR showed that nearly half of the hamadryas (20 out of 40) and hybrid (19 out of 50) baboons had STLV-L DNA sequences. In contrast, most of the seropositive anubis baboons and grivet monkeys carried typical STLV-1 but not STLV-L. These observations demonstrate that STLV-L naturally prevails among hamadryas and hybrid baboons at significantly high rates. STLV-1 and -2, the close relative of STLV-L, are believed to have jumped across simian-human barriers, which resulted in widespread infection of HTLV-1 and -2. Further studies are required to know if STLV-L is spreading into human populations.

Original languageEnglish
Pages (from-to)1642-1648
Number of pages7
JournalJournal of Virology
Volume76
Issue number4
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Takemura, T., Yamashita, M., Shimada, M. K., Ohkura, S., Shotake, T., Ikeda, M., Miura, T., & Hayami, M. (2002). High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons. Journal of Virology, 76(4), 1642-1648. https://doi.org/10.1128/JVI.76.4.1642-1648.2002