High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons

Taichiro Takemura, Masahiro Yamashita, Makoto Shimada, Sadayuki Ohkura, Takayoshi Shotake, Mikio Ikeda, Tomoyuki Miura, Masanori Hayami

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Simian T-cell leukemia viruses (STLVs) are the simian counterparts of human T-cell leukemia viruses (HTLVs). A novel, divergent type of STLV (STLV-L) from captive baboons was reported in 1994, but its natural prevalence remained unclear. We investigated the prevalence of STLV-L in 519 blood samples from wild-living nonhuman primates in Ethiopia. Seropositive monkeys having cross-reactive antibodies against HTLV were found among 22 out of 40 hamadryas baboons, 8 of 96 anubis baboons, 24 of 50 baboons that are hybrids between hamadryas and anubis baboons, and 41 of 177 grivet monkeys, but not in 156 gelada baboons. A Western blotting assay showed that sera obtained from seropositive hamadryas and hybrid baboons exhibited STLV-L-like reactivity. A PCR assay successfully amplified STLV sequences, which were subsequently sequenced and confirmed as being closely related to STLV-L. Surprisingly, further PCR showed that nearly half of the hamadryas (20 out of 40) and hybrid (19 out of 50) baboons had STLV-L DNA sequences. In contrast, most of the seropositive anubis baboons and grivet monkeys carried typical STLV-1 but not STLV-L. These observations demonstrate that STLV-L naturally prevails among hamadryas and hybrid baboons at significantly high rates. STLV-1 and -2, the close relative of STLV-L, are believed to have jumped across simian-human barriers, which resulted in widespread infection of HTLV-1 and -2. Further studies are required to know if STLV-L is spreading into human populations.

Original languageEnglish
Pages (from-to)1642-1648
Number of pages7
JournalJournal of Virology
Volume76
Issue number4
DOIs
Publication statusPublished - 05-02-2002

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Simian T-lymphotropic virus 3
T-Cell Leukemia
Papio
leukemia
T-lymphocytes
Viruses
viruses
Papio hamadryas
Deltaretrovirus
monkeys
Cercopithecus aethiops
Theropithecus
Deltaretrovirus Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Takemura, T., Yamashita, M., Shimada, M., Ohkura, S., Shotake, T., Ikeda, M., ... Hayami, M. (2002). High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons. Journal of Virology, 76(4), 1642-1648. https://doi.org/10.1128/JVI.76.4.1642-1648.2002
Takemura, Taichiro ; Yamashita, Masahiro ; Shimada, Makoto ; Ohkura, Sadayuki ; Shotake, Takayoshi ; Ikeda, Mikio ; Miura, Tomoyuki ; Hayami, Masanori. / High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons. In: Journal of Virology. 2002 ; Vol. 76, No. 4. pp. 1642-1648.
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Takemura, T, Yamashita, M, Shimada, M, Ohkura, S, Shotake, T, Ikeda, M, Miura, T & Hayami, M 2002, 'High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons', Journal of Virology, vol. 76, no. 4, pp. 1642-1648. https://doi.org/10.1128/JVI.76.4.1642-1648.2002

High prevalence of simian T-lymphotropic virus type L in wild Ethiopian baboons. / Takemura, Taichiro; Yamashita, Masahiro; Shimada, Makoto; Ohkura, Sadayuki; Shotake, Takayoshi; Ikeda, Mikio; Miura, Tomoyuki; Hayami, Masanori.

In: Journal of Virology, Vol. 76, No. 4, 05.02.2002, p. 1642-1648.

Research output: Contribution to journalArticle

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