High-sensitivity c-reactive protein and coronary heart disease in a general population of Japanese

The Hisayama study

Hisatomi Arima, Michiaki Kubo, Koji Yonemoto, Yasufumi Doi, Toshiharu Ninomiya, Yumihiro Tanizaki, Jun Hata, Kiyoshi Matsumura, Mitsuo Iida, Yutaka Kiyohara

Research output: Contribution to journalArticle

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Abstract

Objective - The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese. Methods and Results - The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors. Conclusions - hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.

Original languageEnglish
Pages (from-to)1385-1391
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume28
Issue number7
DOIs
Publication statusPublished - 01-07-2008
Externally publishedYes

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C-Reactive Protein
Coronary Disease
Population
Proteins
Sudden Cardiac Death
Cohort Studies
Myocardial Infarction
Prospective Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Arima, Hisatomi ; Kubo, Michiaki ; Yonemoto, Koji ; Doi, Yasufumi ; Ninomiya, Toshiharu ; Tanizaki, Yumihiro ; Hata, Jun ; Matsumura, Kiyoshi ; Iida, Mitsuo ; Kiyohara, Yutaka. / High-sensitivity c-reactive protein and coronary heart disease in a general population of Japanese : The Hisayama study. In: Arteriosclerosis, Thrombosis, and Vascular Biology. 2008 ; Vol. 28, No. 7. pp. 1385-1391.
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High-sensitivity c-reactive protein and coronary heart disease in a general population of Japanese : The Hisayama study. / Arima, Hisatomi; Kubo, Michiaki; Yonemoto, Koji; Doi, Yasufumi; Ninomiya, Toshiharu; Tanizaki, Yumihiro; Hata, Jun; Matsumura, Kiyoshi; Iida, Mitsuo; Kiyohara, Yutaka.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28, No. 7, 01.07.2008, p. 1385-1391.

Research output: Contribution to journalArticle

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T1 - High-sensitivity c-reactive protein and coronary heart disease in a general population of Japanese

T2 - The Hisayama study

AU - Arima, Hisatomi

AU - Kubo, Michiaki

AU - Yonemoto, Koji

AU - Doi, Yasufumi

AU - Ninomiya, Toshiharu

AU - Tanizaki, Yumihiro

AU - Hata, Jun

AU - Matsumura, Kiyoshi

AU - Iida, Mitsuo

AU - Kiyohara, Yutaka

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Objective - The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese. Methods and Results - The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors. Conclusions - hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.

AB - Objective - The purpose of this study was to investigate the effects of high-sensitivity C-reactive protein (hs-CRP) on the risks of coronary heart disease (CHD) in a general population of Japanese. Methods and Results - The Hisayama study is a population-based prospective cohort study. A total of 2589 participants aged 40 years or older were followed up for 14 years. Outcomes are incident CHD (myocardial infarction, coronary revascularization, and sudden cardiac death). The median hs-CRP level was 0.43 mg/L at baseline. During the follow-up period, 129 coronary events were observed. Age- and sex-adjusted annual incidence rates of CHD rose progressively with higher hs-CRP levels: 1.6, 3.3, 4.5, and 7.4 per 1000 person-years for quartile groups defined by hs-CRP levels of <0.21, 0.21 to 0.43, 0.44 to 1.02, and >1.02 mg/L, respectively (P<0.0001 for trend). The risk of CHD in the highest quartile group was 2.98-fold (95% CI, 1.53 to 5.82) higher than that in the lowest group even after controlling for other cardiovascular risk factors. Conclusions - hs-CRP levels were clearly associated with future CHD events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.

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