Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese

Takashi Muramatsu, Hiroshi Yatsuya, Hideaki Toyoshima, Satoshi Sasaki, Enei Ri, Rei Otsuka, Keiko Wada, Yo Hotta, Hirotsugu Mitsuhashi, Kunihiro Matsushita, Toyoaki Murohara, Koji Tamakoshi

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA. +. DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. Method: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA. +. DHA intake as the reference were calculated by logistic regression analysis. Results: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9years, 22.9kg/m2, and 1.90g/day (0.88%E) and 0.77g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25kg/m2 (P for interaction=0.033). However EPA+DHA showed no such associations consistently. Conclusion: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalPreventive Medicine
Volume50
Issue number5-6
DOIs
Publication statusPublished - 01-05-2010
Externally publishedYes

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alpha-Linolenic Acid
Insulin Resistance
Odds Ratio
Omega-3 Fatty Acids
Body Mass Index
Local Government
Eicosapentaenoic Acid
Docosahexaenoic Acids
Homeostasis
Logistic Models
Regression Analysis
Diet
Weights and Measures
Food
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Muramatsu, Takashi ; Yatsuya, Hiroshi ; Toyoshima, Hideaki ; Sasaki, Satoshi ; Ri, Enei ; Otsuka, Rei ; Wada, Keiko ; Hotta, Yo ; Mitsuhashi, Hirotsugu ; Matsushita, Kunihiro ; Murohara, Toyoaki ; Tamakoshi, Koji. / Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. In: Preventive Medicine. 2010 ; Vol. 50, No. 5-6. pp. 272-276.
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abstract = "Objective: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA. +. DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. Method: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA. +. DHA intake as the reference were calculated by logistic regression analysis. Results: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9years, 22.9kg/m2, and 1.90g/day (0.88{\%}E) and 0.77g/day (0.36{\%}E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25kg/m2 (P for interaction=0.033). However EPA+DHA showed no such associations consistently. Conclusion: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.",
author = "Takashi Muramatsu and Hiroshi Yatsuya and Hideaki Toyoshima and Satoshi Sasaki and Enei Ri and Rei Otsuka and Keiko Wada and Yo Hotta and Hirotsugu Mitsuhashi and Kunihiro Matsushita and Toyoaki Murohara and Koji Tamakoshi",
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Muramatsu, T, Yatsuya, H, Toyoshima, H, Sasaki, S, Ri, E, Otsuka, R, Wada, K, Hotta, Y, Mitsuhashi, H, Matsushita, K, Murohara, T & Tamakoshi, K 2010, 'Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese', Preventive Medicine, vol. 50, no. 5-6, pp. 272-276. https://doi.org/10.1016/j.ypmed.2010.02.014

Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese. / Muramatsu, Takashi; Yatsuya, Hiroshi; Toyoshima, Hideaki; Sasaki, Satoshi; Ri, Enei; Otsuka, Rei; Wada, Keiko; Hotta, Yo; Mitsuhashi, Hirotsugu; Matsushita, Kunihiro; Murohara, Toyoaki; Tamakoshi, Koji.

In: Preventive Medicine, Vol. 50, No. 5-6, 01.05.2010, p. 272-276.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Higher dietary intake of alpha-linolenic acid is associated with lower insulin resistance in middle-aged Japanese

AU - Muramatsu, Takashi

AU - Yatsuya, Hiroshi

AU - Toyoshima, Hideaki

AU - Sasaki, Satoshi

AU - Ri, Enei

AU - Otsuka, Rei

AU - Wada, Keiko

AU - Hotta, Yo

AU - Mitsuhashi, Hirotsugu

AU - Matsushita, Kunihiro

AU - Murohara, Toyoaki

AU - Tamakoshi, Koji

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Objective: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA. +. DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. Method: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA. +. DHA intake as the reference were calculated by logistic regression analysis. Results: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9years, 22.9kg/m2, and 1.90g/day (0.88%E) and 0.77g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25kg/m2 (P for interaction=0.033). However EPA+DHA showed no such associations consistently. Conclusion: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

AB - Objective: To investigate the associations between dietary intake of n-3 polyunsaturated fatty acids (plant-derived alpha-linolenic acid: ALA, and marine-derived eicosapentaenoic and docosahexaenoic acid: EPA. +. DHA) and insulin resistance (IR) in a lean population with high n-3 PUFA intake. Method: We cross-sectionally studied 3383 Japanese local government workers aged 35-66 in 2002. IR was defined as the highest quartile of homeostasis model assessment, and nutrient intake was estimated from a diet history questionnaire. The odds ratios (ORs) of IR taking the lowest quartile of ALA or EPA. +. DHA intake as the reference were calculated by logistic regression analysis. Results: Mean age, body mass index (BMI), and dietary ALA, and median of dietary EPA+DHA were 47.9years, 22.9kg/m2, and 1.90g/day (0.88%E) and 0.77g/day (0.36%E), respectively. The ORs of IR decreased across the quartiles of ALA intake (multivariate-adjusted OR for Q4 versus Q1=0.74, P for trend=0.01) and the association was observed only in subjects with a BMI of <25kg/m2 (P for interaction=0.033). However EPA+DHA showed no such associations consistently. Conclusion: Higher ALA intake was significantly associated with a lower prevalence of IR in normal weight individuals of middle-aged Japanese men and women.

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