TY - JOUR
T1 - Highly concordant coexpression of aromatase and estrogen receptor β in non-small cell lung cancer
AU - Abe, Keiko
AU - Miki, Yasuhiro
AU - Ono, Katsuhiko
AU - Mori, Miki
AU - Kakinuma, Hideaki
AU - Kou, Yuki
AU - Kudo, Nobutaka
AU - Koguchi, Masashi
AU - Niikawa, Hiromichi
AU - Suzuki, Satoshi
AU - Evans, Dean B.
AU - Sugawara, Shunichi
AU - Suzuki, Takashi
AU - Sasano, Hironobu
N1 - Funding Information:
This work was supported, in part, by a grant-in-aid for Scientific Research from the Ministry of Health and Welfare, and a grant-in-aid from the Ministry of Education, Science and Culture.
PY - 2010/2
Y1 - 2010/2
N2 - Estrogen receptor expression has been reported in non-small cell lung cancer. We examined the correlation between aromatase, a key enzyme in the synthesis of estrogen, and estrogen receptor expressions in 105 non-small cell lung cancer cases. All patients were older than 60 years, and all female patients were postmenopausal. Estrogen receptor α and progesterone receptor were detected in only 1 and 14 cases, respectively. Estrogen receptor β and aromatase were positive in 75 and 89 cases respectively. Estrogen receptor β expression in non-small cell lung cancer showed an inverse correlation with lymph node metastasis (P < .05). Only among females, both estrogen receptor β and aromatase expressions were correlated with higher Ki-67 labeling index and younger age (P < .05). Among 89 aromatase-positive cases, 70 were positive for estrogen receptor β, demonstrating a significant concordance (P < .05). Simultaneous immunohistochemical staining for aromatase and estrogen receptor β showed a high rate of double positive association. Male non-small cell lung cancer cases with double positivity for aromatase and estrogen receptor β demonstrated lower status in N factor by TNM classification (P < .05). In addition, among 89 aromatase-positive cases, a low-Allred total score of estrogen receptor β showed a significant relationship with large tumor size and high T factor by TNM classification (P < .05). In conclusion, frequent coexpression of aromatase and estrogen receptor β in non-small cell lung cancer might suggest some functional correlation between aromatase and estrogen receptor β, whereas estrogen receptor β negativity might be correlated with malignant progression of non-small cell lung cancer.
AB - Estrogen receptor expression has been reported in non-small cell lung cancer. We examined the correlation between aromatase, a key enzyme in the synthesis of estrogen, and estrogen receptor expressions in 105 non-small cell lung cancer cases. All patients were older than 60 years, and all female patients were postmenopausal. Estrogen receptor α and progesterone receptor were detected in only 1 and 14 cases, respectively. Estrogen receptor β and aromatase were positive in 75 and 89 cases respectively. Estrogen receptor β expression in non-small cell lung cancer showed an inverse correlation with lymph node metastasis (P < .05). Only among females, both estrogen receptor β and aromatase expressions were correlated with higher Ki-67 labeling index and younger age (P < .05). Among 89 aromatase-positive cases, 70 were positive for estrogen receptor β, demonstrating a significant concordance (P < .05). Simultaneous immunohistochemical staining for aromatase and estrogen receptor β showed a high rate of double positive association. Male non-small cell lung cancer cases with double positivity for aromatase and estrogen receptor β demonstrated lower status in N factor by TNM classification (P < .05). In addition, among 89 aromatase-positive cases, a low-Allred total score of estrogen receptor β showed a significant relationship with large tumor size and high T factor by TNM classification (P < .05). In conclusion, frequent coexpression of aromatase and estrogen receptor β in non-small cell lung cancer might suggest some functional correlation between aromatase and estrogen receptor β, whereas estrogen receptor β negativity might be correlated with malignant progression of non-small cell lung cancer.
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U2 - 10.1016/j.humpath.2009.07.010
DO - 10.1016/j.humpath.2009.07.010
M3 - Article
C2 - 19800101
AN - SCOPUS:73749086568
SN - 0046-8177
VL - 41
SP - 190
EP - 198
JO - Human Pathology
JF - Human Pathology
IS - 2
ER -
