Hippocampal neurogenesis regulates forgetting during adulthood and infancy

Katherine G. Akers, Alonso Martinez-Canabal, Leonardo Restivo, Adelaide P. Yiu, Antonietta De Cristofaro, Hwa Lin Hsiang, Anne L. Wheeler, Axel Guskjolen, Yosuke Niibori, Hirotaka Shoji, Koji Ohira, Blake A. Richards, Tsuyoshi Miyakawa, Sheena A. Josselyn, Paul W. Frankland

Research output: Contribution to journalArticle

288 Citations (Scopus)

Abstract

Throughout life, new neurons are continuously added to the dentate gyrus. As this continuous addition remodels hippocampal circuits, computational models predict that neurogenesis leads to degradation or forgetting of established memories. Consistent with this, increasing neurogenesis after the formation of a memory was sufficient to induce forgetting in adult mice. By contrast, during infancy, when hippocampal neurogenesis levels are high and freshly generated memories tend to be rapidly forgotten (infantile amnesia), decreasing neurogenesis after memory formation mitigated forgetting. In precocial species, including guinea pigs and degus, most granule cells are generated prenatally. Consistent with reduced levels of postnatal hippocampal neurogenesis, infant guinea pigs and degus did not exhibit forgetting. However, increasing neurogenesis after memory formation induced infantile amnesia in these species.

Original languageEnglish
Pages (from-to)598-602
Number of pages5
JournalScience
Volume344
Issue number6184
DOIs
Publication statusPublished - 01-01-2014

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Neurogenesis
Amnesia
Guinea Pigs
Dentate Gyrus
Neurons

All Science Journal Classification (ASJC) codes

  • General

Cite this

Akers, K. G., Martinez-Canabal, A., Restivo, L., Yiu, A. P., De Cristofaro, A., Hsiang, H. L., ... Frankland, P. W. (2014). Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science, 344(6184), 598-602. https://doi.org/10.1126/science.1248903
Akers, Katherine G. ; Martinez-Canabal, Alonso ; Restivo, Leonardo ; Yiu, Adelaide P. ; De Cristofaro, Antonietta ; Hsiang, Hwa Lin ; Wheeler, Anne L. ; Guskjolen, Axel ; Niibori, Yosuke ; Shoji, Hirotaka ; Ohira, Koji ; Richards, Blake A. ; Miyakawa, Tsuyoshi ; Josselyn, Sheena A. ; Frankland, Paul W. / Hippocampal neurogenesis regulates forgetting during adulthood and infancy. In: Science. 2014 ; Vol. 344, No. 6184. pp. 598-602.
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Akers, KG, Martinez-Canabal, A, Restivo, L, Yiu, AP, De Cristofaro, A, Hsiang, HL, Wheeler, AL, Guskjolen, A, Niibori, Y, Shoji, H, Ohira, K, Richards, BA, Miyakawa, T, Josselyn, SA & Frankland, PW 2014, 'Hippocampal neurogenesis regulates forgetting during adulthood and infancy', Science, vol. 344, no. 6184, pp. 598-602. https://doi.org/10.1126/science.1248903

Hippocampal neurogenesis regulates forgetting during adulthood and infancy. / Akers, Katherine G.; Martinez-Canabal, Alonso; Restivo, Leonardo; Yiu, Adelaide P.; De Cristofaro, Antonietta; Hsiang, Hwa Lin; Wheeler, Anne L.; Guskjolen, Axel; Niibori, Yosuke; Shoji, Hirotaka; Ohira, Koji; Richards, Blake A.; Miyakawa, Tsuyoshi; Josselyn, Sheena A.; Frankland, Paul W.

In: Science, Vol. 344, No. 6184, 01.01.2014, p. 598-602.

Research output: Contribution to journalArticle

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Akers KG, Martinez-Canabal A, Restivo L, Yiu AP, De Cristofaro A, Hsiang HL et al. Hippocampal neurogenesis regulates forgetting during adulthood and infancy. Science. 2014 Jan 1;344(6184):598-602. https://doi.org/10.1126/science.1248903