Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment

Hiroko Kondo, Minori Kurahashi, Daisuke Mori, Mitsuo Iinuma, Yasuo Tamura, Kenmei Mizutani, Kan Shimpo, Shigeru Sonoda, Kagaku Azuma, Kin Ya Kubo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and objective Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Exposure to an enriched environment restores the reduced hippocampal function. Here, we explored the effects of an enriched environment on learning deficits and hippocampal morphologic changes in aged senescence-accelerated mouse strain P8 (SAMP8) mice with tooth loss. Design Eight-month-old male aged SAMP8 mice with molar intact or with molars removed were housed in either a standard environment or enriched environment for 3 weeks. The Morris water maze was performed for spatial memory test. The newborn cell proliferation, survival, and differentiation in the hippocampus were analyzed using 5-Bromodeoxyuridine (BrdU) immunohistochemical method. The hippocampal brain-derived neurotrophic factor (BDNF) levels were also measured. Results Mice with upper molars removed (molarless) exhibited a significant decline in the proliferation and survival of newborn cells in the dentate gyrus (DG) as well as in hippocampal BDNF levels. In addition, neuronal differentiation of newly generated cells was suppressed and hippocampus-dependent spatial memory was impaired. Exposure of molarless mice to an enriched environment attenuated the reductions in the hippocampal BDNF levels and neuronal differentiation, and partially improved the proliferation and survival of newborn cells, as well as the spatial memory ability. Conclusion These findings indicated that an enriched environment could ameliorate the hippocampus-dependent spatial memory impairment induced by molar tooth loss.

Original languageEnglish
Article number3473
Pages (from-to)1-7
Number of pages7
JournalArchives of Oral Biology
Volume61
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Tooth Loss
Hippocampus
Brain-Derived Neurotrophic Factor
Cell Survival
Learning
Mastication
Dentate Gyrus
Bromodeoxyuridine
Spatial Memory
Cognition
Cell Differentiation
Tooth
Cell Proliferation
Water
Health

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

Cite this

Kondo, Hiroko ; Kurahashi, Minori ; Mori, Daisuke ; Iinuma, Mitsuo ; Tamura, Yasuo ; Mizutani, Kenmei ; Shimpo, Kan ; Sonoda, Shigeru ; Azuma, Kagaku ; Kubo, Kin Ya. / Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment. In: Archives of Oral Biology. 2016 ; Vol. 61. pp. 1-7.
@article{68ae9b78981e4159b4f2d65ec37ebbff,
title = "Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment",
abstract = "Background and objective Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Exposure to an enriched environment restores the reduced hippocampal function. Here, we explored the effects of an enriched environment on learning deficits and hippocampal morphologic changes in aged senescence-accelerated mouse strain P8 (SAMP8) mice with tooth loss. Design Eight-month-old male aged SAMP8 mice with molar intact or with molars removed were housed in either a standard environment or enriched environment for 3 weeks. The Morris water maze was performed for spatial memory test. The newborn cell proliferation, survival, and differentiation in the hippocampus were analyzed using 5-Bromodeoxyuridine (BrdU) immunohistochemical method. The hippocampal brain-derived neurotrophic factor (BDNF) levels were also measured. Results Mice with upper molars removed (molarless) exhibited a significant decline in the proliferation and survival of newborn cells in the dentate gyrus (DG) as well as in hippocampal BDNF levels. In addition, neuronal differentiation of newly generated cells was suppressed and hippocampus-dependent spatial memory was impaired. Exposure of molarless mice to an enriched environment attenuated the reductions in the hippocampal BDNF levels and neuronal differentiation, and partially improved the proliferation and survival of newborn cells, as well as the spatial memory ability. Conclusion These findings indicated that an enriched environment could ameliorate the hippocampus-dependent spatial memory impairment induced by molar tooth loss.",
author = "Hiroko Kondo and Minori Kurahashi and Daisuke Mori and Mitsuo Iinuma and Yasuo Tamura and Kenmei Mizutani and Kan Shimpo and Shigeru Sonoda and Kagaku Azuma and Kubo, {Kin Ya}",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.archoralbio.2015.10.006",
language = "English",
volume = "61",
pages = "1--7",
journal = "Archives of Oral Biology",
issn = "0003-9969",
publisher = "Elsevier Limited",

}

Kondo, H, Kurahashi, M, Mori, D, Iinuma, M, Tamura, Y, Mizutani, K, Shimpo, K, Sonoda, S, Azuma, K & Kubo, KY 2016, 'Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment', Archives of Oral Biology, vol. 61, 3473, pp. 1-7. https://doi.org/10.1016/j.archoralbio.2015.10.006

Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment. / Kondo, Hiroko; Kurahashi, Minori; Mori, Daisuke; Iinuma, Mitsuo; Tamura, Yasuo; Mizutani, Kenmei; Shimpo, Kan; Sonoda, Shigeru; Azuma, Kagaku; Kubo, Kin Ya.

In: Archives of Oral Biology, Vol. 61, 3473, 01.01.2016, p. 1-7.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment

AU - Kondo, Hiroko

AU - Kurahashi, Minori

AU - Mori, Daisuke

AU - Iinuma, Mitsuo

AU - Tamura, Yasuo

AU - Mizutani, Kenmei

AU - Shimpo, Kan

AU - Sonoda, Shigeru

AU - Azuma, Kagaku

AU - Kubo, Kin Ya

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background and objective Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Exposure to an enriched environment restores the reduced hippocampal function. Here, we explored the effects of an enriched environment on learning deficits and hippocampal morphologic changes in aged senescence-accelerated mouse strain P8 (SAMP8) mice with tooth loss. Design Eight-month-old male aged SAMP8 mice with molar intact or with molars removed were housed in either a standard environment or enriched environment for 3 weeks. The Morris water maze was performed for spatial memory test. The newborn cell proliferation, survival, and differentiation in the hippocampus were analyzed using 5-Bromodeoxyuridine (BrdU) immunohistochemical method. The hippocampal brain-derived neurotrophic factor (BDNF) levels were also measured. Results Mice with upper molars removed (molarless) exhibited a significant decline in the proliferation and survival of newborn cells in the dentate gyrus (DG) as well as in hippocampal BDNF levels. In addition, neuronal differentiation of newly generated cells was suppressed and hippocampus-dependent spatial memory was impaired. Exposure of molarless mice to an enriched environment attenuated the reductions in the hippocampal BDNF levels and neuronal differentiation, and partially improved the proliferation and survival of newborn cells, as well as the spatial memory ability. Conclusion These findings indicated that an enriched environment could ameliorate the hippocampus-dependent spatial memory impairment induced by molar tooth loss.

AB - Background and objective Teeth are crucial, not only for mastication, but for overall nutrition and general health, including cognitive function. Aged mice with chronic stress due to tooth loss exhibit impaired hippocampus-dependent learning and memory. Exposure to an enriched environment restores the reduced hippocampal function. Here, we explored the effects of an enriched environment on learning deficits and hippocampal morphologic changes in aged senescence-accelerated mouse strain P8 (SAMP8) mice with tooth loss. Design Eight-month-old male aged SAMP8 mice with molar intact or with molars removed were housed in either a standard environment or enriched environment for 3 weeks. The Morris water maze was performed for spatial memory test. The newborn cell proliferation, survival, and differentiation in the hippocampus were analyzed using 5-Bromodeoxyuridine (BrdU) immunohistochemical method. The hippocampal brain-derived neurotrophic factor (BDNF) levels were also measured. Results Mice with upper molars removed (molarless) exhibited a significant decline in the proliferation and survival of newborn cells in the dentate gyrus (DG) as well as in hippocampal BDNF levels. In addition, neuronal differentiation of newly generated cells was suppressed and hippocampus-dependent spatial memory was impaired. Exposure of molarless mice to an enriched environment attenuated the reductions in the hippocampal BDNF levels and neuronal differentiation, and partially improved the proliferation and survival of newborn cells, as well as the spatial memory ability. Conclusion These findings indicated that an enriched environment could ameliorate the hippocampus-dependent spatial memory impairment induced by molar tooth loss.

UR - http://www.scopus.com/inward/record.url?scp=84944346032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944346032&partnerID=8YFLogxK

U2 - 10.1016/j.archoralbio.2015.10.006

DO - 10.1016/j.archoralbio.2015.10.006

M3 - Article

VL - 61

SP - 1

EP - 7

JO - Archives of Oral Biology

JF - Archives of Oral Biology

SN - 0003-9969

M1 - 3473

ER -