Histological differences in new-onset IgA nephropathy between children and adults

Yohei Ikezumi, Toshiaki Suzuki, Naofumi Imai, Mitsuhiro Ueno, Ichiei Narita, Hiroshi Kawachi, Fujio Shimizu, David J. Nikolic-Paterson, Makoto Uchiyama

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background. It is suggested that IgA nephropathy (IgAN) manifests differently in children vs adults on the basis of biopsy findings. However, this has been difficult to establish owing to the uncertainty of the timing of disease onset in adult IgAN. We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN. Methods. Biopsies taken within 2 years from the onset of renal abnormalities in 33 childhood (10 ± 3 years of age) and 38 adult (35 ± 6 years) cases of IgAN were examined for histological changes (cellularity in mesangial, endocapillary and extracapillary areas, matrix expansion, adhesions/crescents and interstitial damage), glomerular deposition of immunoglobulin and complement, and the presence of macrophages, activated macrophages and T cells by immunohistochemistry. Results. Glomerular hypercellularity owing to increased cells in mesangial area was prominent in paediatric IgAN and significantly greater than in adult IgAN. In contrast, glomerular matrix expansion, crescent formation and interstitial damage were more severe in adults compared to paediatric IgAN. Indeed, glomerular hypercellularity correlated with proteinuria in paediatric but not in adult IgAN, whereas glomerular matrix correlated with proteinuria and renal function in adult but not in paediatric IgAN. The degree of C3c deposition was significantly greater in paediatric IgAN, while deposition of fibrinogen was greater in adult IgAN. Glomerular and interstitial CD68+ macrophages and a subset of sialoadhesin (Sn)+ activated macrophages were identified in both paediatric and adult IgAN, being significantly greater in number in adult IgAN. Glomerular leucocyte infiltration correlated with proteinuria while interstitial leucocyte infiltration correlated with interstitial damage in both groups. However, only the subset of Sn+ macrophages gave a significant correlation with renal function, glomerular hypercellularity and glomerular matrix. Conclusions. This study has demonstrated significant differences in the early glomerular lesions of IgAN in children vs adults. Furthermore, Sn+ activated macrophages are implicated in the pathogenesis of IgAN in both patient groups. The prognostic significance of these findings warrants further study.

Original languageEnglish
Pages (from-to)3466-3474
Number of pages9
JournalNephrology Dialysis Transplantation
Volume21
Issue number12
DOIs
Publication statusPublished - 01-12-2006

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Immunoglobulin A
Sialic Acid Binding Ig-like Lectin 1
Macrophages
Pediatrics
Proteinuria
Leukocytes
Kidney
Biopsy
Mesangial Cells
Fibrinogen
Uncertainty
Immunoglobulins
Histology
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Transplantation

Cite this

Ikezumi, Yohei ; Suzuki, Toshiaki ; Imai, Naofumi ; Ueno, Mitsuhiro ; Narita, Ichiei ; Kawachi, Hiroshi ; Shimizu, Fujio ; Nikolic-Paterson, David J. ; Uchiyama, Makoto. / Histological differences in new-onset IgA nephropathy between children and adults. In: Nephrology Dialysis Transplantation. 2006 ; Vol. 21, No. 12. pp. 3466-3474.
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title = "Histological differences in new-onset IgA nephropathy between children and adults",
abstract = "Background. It is suggested that IgA nephropathy (IgAN) manifests differently in children vs adults on the basis of biopsy findings. However, this has been difficult to establish owing to the uncertainty of the timing of disease onset in adult IgAN. We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN. Methods. Biopsies taken within 2 years from the onset of renal abnormalities in 33 childhood (10 ± 3 years of age) and 38 adult (35 ± 6 years) cases of IgAN were examined for histological changes (cellularity in mesangial, endocapillary and extracapillary areas, matrix expansion, adhesions/crescents and interstitial damage), glomerular deposition of immunoglobulin and complement, and the presence of macrophages, activated macrophages and T cells by immunohistochemistry. Results. Glomerular hypercellularity owing to increased cells in mesangial area was prominent in paediatric IgAN and significantly greater than in adult IgAN. In contrast, glomerular matrix expansion, crescent formation and interstitial damage were more severe in adults compared to paediatric IgAN. Indeed, glomerular hypercellularity correlated with proteinuria in paediatric but not in adult IgAN, whereas glomerular matrix correlated with proteinuria and renal function in adult but not in paediatric IgAN. The degree of C3c deposition was significantly greater in paediatric IgAN, while deposition of fibrinogen was greater in adult IgAN. Glomerular and interstitial CD68+ macrophages and a subset of sialoadhesin (Sn)+ activated macrophages were identified in both paediatric and adult IgAN, being significantly greater in number in adult IgAN. Glomerular leucocyte infiltration correlated with proteinuria while interstitial leucocyte infiltration correlated with interstitial damage in both groups. However, only the subset of Sn+ macrophages gave a significant correlation with renal function, glomerular hypercellularity and glomerular matrix. Conclusions. This study has demonstrated significant differences in the early glomerular lesions of IgAN in children vs adults. Furthermore, Sn+ activated macrophages are implicated in the pathogenesis of IgAN in both patient groups. The prognostic significance of these findings warrants further study.",
author = "Yohei Ikezumi and Toshiaki Suzuki and Naofumi Imai and Mitsuhiro Ueno and Ichiei Narita and Hiroshi Kawachi and Fujio Shimizu and Nikolic-Paterson, {David J.} and Makoto Uchiyama",
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Ikezumi, Y, Suzuki, T, Imai, N, Ueno, M, Narita, I, Kawachi, H, Shimizu, F, Nikolic-Paterson, DJ & Uchiyama, M 2006, 'Histological differences in new-onset IgA nephropathy between children and adults', Nephrology Dialysis Transplantation, vol. 21, no. 12, pp. 3466-3474. https://doi.org/10.1093/ndt/gfl455

Histological differences in new-onset IgA nephropathy between children and adults. / Ikezumi, Yohei; Suzuki, Toshiaki; Imai, Naofumi; Ueno, Mitsuhiro; Narita, Ichiei; Kawachi, Hiroshi; Shimizu, Fujio; Nikolic-Paterson, David J.; Uchiyama, Makoto.

In: Nephrology Dialysis Transplantation, Vol. 21, No. 12, 01.12.2006, p. 3466-3474.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Histological differences in new-onset IgA nephropathy between children and adults

AU - Ikezumi, Yohei

AU - Suzuki, Toshiaki

AU - Imai, Naofumi

AU - Ueno, Mitsuhiro

AU - Narita, Ichiei

AU - Kawachi, Hiroshi

AU - Shimizu, Fujio

AU - Nikolic-Paterson, David J.

AU - Uchiyama, Makoto

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Background. It is suggested that IgA nephropathy (IgAN) manifests differently in children vs adults on the basis of biopsy findings. However, this has been difficult to establish owing to the uncertainty of the timing of disease onset in adult IgAN. We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN. Methods. Biopsies taken within 2 years from the onset of renal abnormalities in 33 childhood (10 ± 3 years of age) and 38 adult (35 ± 6 years) cases of IgAN were examined for histological changes (cellularity in mesangial, endocapillary and extracapillary areas, matrix expansion, adhesions/crescents and interstitial damage), glomerular deposition of immunoglobulin and complement, and the presence of macrophages, activated macrophages and T cells by immunohistochemistry. Results. Glomerular hypercellularity owing to increased cells in mesangial area was prominent in paediatric IgAN and significantly greater than in adult IgAN. In contrast, glomerular matrix expansion, crescent formation and interstitial damage were more severe in adults compared to paediatric IgAN. Indeed, glomerular hypercellularity correlated with proteinuria in paediatric but not in adult IgAN, whereas glomerular matrix correlated with proteinuria and renal function in adult but not in paediatric IgAN. The degree of C3c deposition was significantly greater in paediatric IgAN, while deposition of fibrinogen was greater in adult IgAN. Glomerular and interstitial CD68+ macrophages and a subset of sialoadhesin (Sn)+ activated macrophages were identified in both paediatric and adult IgAN, being significantly greater in number in adult IgAN. Glomerular leucocyte infiltration correlated with proteinuria while interstitial leucocyte infiltration correlated with interstitial damage in both groups. However, only the subset of Sn+ macrophages gave a significant correlation with renal function, glomerular hypercellularity and glomerular matrix. Conclusions. This study has demonstrated significant differences in the early glomerular lesions of IgAN in children vs adults. Furthermore, Sn+ activated macrophages are implicated in the pathogenesis of IgAN in both patient groups. The prognostic significance of these findings warrants further study.

AB - Background. It is suggested that IgA nephropathy (IgAN) manifests differently in children vs adults on the basis of biopsy findings. However, this has been difficult to establish owing to the uncertainty of the timing of disease onset in adult IgAN. We addressed this question by comparing both histology and leucocyte accumulation in biopsies of recently diagnosed childhood and adult IgAN. Methods. Biopsies taken within 2 years from the onset of renal abnormalities in 33 childhood (10 ± 3 years of age) and 38 adult (35 ± 6 years) cases of IgAN were examined for histological changes (cellularity in mesangial, endocapillary and extracapillary areas, matrix expansion, adhesions/crescents and interstitial damage), glomerular deposition of immunoglobulin and complement, and the presence of macrophages, activated macrophages and T cells by immunohistochemistry. Results. Glomerular hypercellularity owing to increased cells in mesangial area was prominent in paediatric IgAN and significantly greater than in adult IgAN. In contrast, glomerular matrix expansion, crescent formation and interstitial damage were more severe in adults compared to paediatric IgAN. Indeed, glomerular hypercellularity correlated with proteinuria in paediatric but not in adult IgAN, whereas glomerular matrix correlated with proteinuria and renal function in adult but not in paediatric IgAN. The degree of C3c deposition was significantly greater in paediatric IgAN, while deposition of fibrinogen was greater in adult IgAN. Glomerular and interstitial CD68+ macrophages and a subset of sialoadhesin (Sn)+ activated macrophages were identified in both paediatric and adult IgAN, being significantly greater in number in adult IgAN. Glomerular leucocyte infiltration correlated with proteinuria while interstitial leucocyte infiltration correlated with interstitial damage in both groups. However, only the subset of Sn+ macrophages gave a significant correlation with renal function, glomerular hypercellularity and glomerular matrix. Conclusions. This study has demonstrated significant differences in the early glomerular lesions of IgAN in children vs adults. Furthermore, Sn+ activated macrophages are implicated in the pathogenesis of IgAN in both patient groups. The prognostic significance of these findings warrants further study.

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