TY - JOUR
T1 - Histological effect of basic fibroblast growth factor on chronic vocal fold scarring in a rat model
AU - Tateya, Ichiro
AU - Tateya, Tomoko
AU - Sohn, Jin Ho
AU - Bless, Diane M.
N1 - Publisher Copyright:
© 2016 by Korean Society of Otorhinolaryngology-Head and Neck Surgery.
PY - 2016/3
Y1 - 2016/3
N2 - Objectives. Vocal fold scarring is one of the most challenging laryngeal disorders to treat and there are currently no consistently effective treatments available. Our previous studies have shown the therapeutic potential of basic fibroblast growth factor (bFGF) for vocal fold scarring. However, the histological effects of bFGF on scarred vocal fold have not been elucidated. The aim of this study was to examine the histological effects of bFGF on chronic vocal fold scarring. Methods. Sprague-Dawley rats were divided into phosphate buffered saline (sham) and bFGF groups. Unilateral vocal fold stripping was performed and the drug was injected into the scarred vocal fold for each group 2 months postoperatively. Injections were performed weekly for 4 weeks. Two months after the last injection, larynges were harvested and histologically analyzed. Results. A significant increase of hyaluronic acid was observed in the vocal fold of the bFGF group compared with that of the sham group. However, there was no remarkable change in collagen expression nor in vocal fold contraction. Conclusion. Significant increase of hyaluronic acid by local bFGF injection was thought to contribute to the therapeutic effects on chronic vocal fold scarring.
AB - Objectives. Vocal fold scarring is one of the most challenging laryngeal disorders to treat and there are currently no consistently effective treatments available. Our previous studies have shown the therapeutic potential of basic fibroblast growth factor (bFGF) for vocal fold scarring. However, the histological effects of bFGF on scarred vocal fold have not been elucidated. The aim of this study was to examine the histological effects of bFGF on chronic vocal fold scarring. Methods. Sprague-Dawley rats were divided into phosphate buffered saline (sham) and bFGF groups. Unilateral vocal fold stripping was performed and the drug was injected into the scarred vocal fold for each group 2 months postoperatively. Injections were performed weekly for 4 weeks. Two months after the last injection, larynges were harvested and histologically analyzed. Results. A significant increase of hyaluronic acid was observed in the vocal fold of the bFGF group compared with that of the sham group. However, there was no remarkable change in collagen expression nor in vocal fold contraction. Conclusion. Significant increase of hyaluronic acid by local bFGF injection was thought to contribute to the therapeutic effects on chronic vocal fold scarring.
UR - http://www.scopus.com/inward/record.url?scp=84960403680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960403680&partnerID=8YFLogxK
U2 - 10.21053/ceo.2016.9.1.56
DO - 10.21053/ceo.2016.9.1.56
M3 - Article
AN - SCOPUS:84960403680
SN - 1976-8710
VL - 9
SP - 56
EP - 61
JO - Clinical and Experimental Otorhinolaryngology
JF - Clinical and Experimental Otorhinolaryngology
IS - 1
ER -