Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer

Mikado Imura; Koichi Yamazaki; Kanako C. Kubota; Tomoo Itoh; Rikiya Onimaru; Yasushi Cho; Yasuhiro Hida; Kichizo Kaga; Yuya Onodera; Shigeaki Ogura; Hirotoshi Dosaka-Akita; Hiroki Shirato; Masaharu Nishimura

doi:10.1016/j.ijrobp.2007.06.064

Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer

Mikado Imura, Koichi Yamazaki, Kanako C. Kubota, Tomoo Itoh, Rikiya Onimaru, Yasushi Cho, Yasuhiro Hida, Kichizo Kaga, Yuya Onodera, Shigeaki Ogura, Hirotoshi Dosaka-Akita, Hiroki Shirato, Masaharu Nishimura

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Purpose: Internal fiducial gold markers, safely inserted with bronchoscopy, have been used in real-time tumor-tracking radiotherapy for lung cancer. We investigated the histopathologic findings at several points after the insertion of the gold markers. Methods and Materials: Sixteen gold markers were inserted for preoperative marking in 7 patients who subsequently underwent partial resection of tumors by video-assisted thoracoscopic surgery within 7 days. Results: Fibrotic changes and hyperplasia of type 2 pneumocytes around the markers were seen 5 or 7 days after insertion, and fibrin exudation without fibrosis was detected 1 or 2 days after insertion. Conclusions: Because fibroblastic changes start approximately 5 days after gold marker insertion, real-time tumor-tracking radiotherapy should be started >5 days after gold marker insertion.

Original language	English
Pages (from-to)	382-384
Number of pages	3
Journal	International Journal of Radiation Oncology Biology Physics
Volume	70
Issue number	2
DOIs	https://doi.org/10.1016/j.ijrobp.2007.06.064
Publication status	Published - 01-02-2008
Externally published	Yes

All Science Journal Classification (ASJC) codes

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijrobp.2007.06.064

Cite this

Imura, M., Yamazaki, K., Kubota, K. C., Itoh, T., Onimaru, R., Cho, Y., Hida, Y., Kaga, K., Onodera, Y., Ogura, S., Dosaka-Akita, H., Shirato, H., & Nishimura, M. (2008). Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer. International Journal of Radiation Oncology Biology Physics, 70(2), 382-384. https://doi.org/10.1016/j.ijrobp.2007.06.064

@article{7abc95fbd4594436b6df7283dfdbe36f,

title = "Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer",

abstract = "Purpose: Internal fiducial gold markers, safely inserted with bronchoscopy, have been used in real-time tumor-tracking radiotherapy for lung cancer. We investigated the histopathologic findings at several points after the insertion of the gold markers. Methods and Materials: Sixteen gold markers were inserted for preoperative marking in 7 patients who subsequently underwent partial resection of tumors by video-assisted thoracoscopic surgery within 7 days. Results: Fibrotic changes and hyperplasia of type 2 pneumocytes around the markers were seen 5 or 7 days after insertion, and fibrin exudation without fibrosis was detected 1 or 2 days after insertion. Conclusions: Because fibroblastic changes start approximately 5 days after gold marker insertion, real-time tumor-tracking radiotherapy should be started >5 days after gold marker insertion.",

author = "Mikado Imura and Koichi Yamazaki and Kubota, {Kanako C.} and Tomoo Itoh and Rikiya Onimaru and Yasushi Cho and Yasuhiro Hida and Kichizo Kaga and Yuya Onodera and Shigeaki Ogura and Hirotoshi Dosaka-Akita and Hiroki Shirato and Masaharu Nishimura",

year = "2008",

month = feb,

day = "1",

doi = "10.1016/j.ijrobp.2007.06.064",

language = "English",

volume = "70",

pages = "382--384",

journal = "International Journal of Radiation Oncology Biology Physics",

issn = "0360-3016",

publisher = "Elsevier Inc.",

number = "2",

}

Imura, M, Yamazaki, K, Kubota, KC, Itoh, T, Onimaru, R, Cho, Y, Hida, Y, Kaga, K, Onodera, Y, Ogura, S, Dosaka-Akita, H, Shirato, H & Nishimura, M 2008, 'Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer', International Journal of Radiation Oncology Biology Physics, vol. 70, no. 2, pp. 382-384. https://doi.org/10.1016/j.ijrobp.2007.06.064

TY - JOUR

T1 - Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer

AU - Imura, Mikado

AU - Yamazaki, Koichi

AU - Kubota, Kanako C.

AU - Itoh, Tomoo

AU - Onimaru, Rikiya

AU - Cho, Yasushi

AU - Hida, Yasuhiro

AU - Kaga, Kichizo

AU - Onodera, Yuya

AU - Ogura, Shigeaki

AU - Dosaka-Akita, Hirotoshi

AU - Shirato, Hiroki

AU - Nishimura, Masaharu

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Purpose: Internal fiducial gold markers, safely inserted with bronchoscopy, have been used in real-time tumor-tracking radiotherapy for lung cancer. We investigated the histopathologic findings at several points after the insertion of the gold markers. Methods and Materials: Sixteen gold markers were inserted for preoperative marking in 7 patients who subsequently underwent partial resection of tumors by video-assisted thoracoscopic surgery within 7 days. Results: Fibrotic changes and hyperplasia of type 2 pneumocytes around the markers were seen 5 or 7 days after insertion, and fibrin exudation without fibrosis was detected 1 or 2 days after insertion. Conclusions: Because fibroblastic changes start approximately 5 days after gold marker insertion, real-time tumor-tracking radiotherapy should be started >5 days after gold marker insertion.

AB - Purpose: Internal fiducial gold markers, safely inserted with bronchoscopy, have been used in real-time tumor-tracking radiotherapy for lung cancer. We investigated the histopathologic findings at several points after the insertion of the gold markers. Methods and Materials: Sixteen gold markers were inserted for preoperative marking in 7 patients who subsequently underwent partial resection of tumors by video-assisted thoracoscopic surgery within 7 days. Results: Fibrotic changes and hyperplasia of type 2 pneumocytes around the markers were seen 5 or 7 days after insertion, and fibrin exudation without fibrosis was detected 1 or 2 days after insertion. Conclusions: Because fibroblastic changes start approximately 5 days after gold marker insertion, real-time tumor-tracking radiotherapy should be started >5 days after gold marker insertion.

UR - http://www.scopus.com/inward/record.url?scp=38149030230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=38149030230&partnerID=8YFLogxK

U2 - 10.1016/j.ijrobp.2007.06.064

DO - 10.1016/j.ijrobp.2007.06.064

M3 - Article

C2 - 17881147

AN - SCOPUS:38149030230

SN - 0360-3016

VL - 70

SP - 382

EP - 384

JO - International Journal of Radiation Oncology Biology Physics

JF - International Journal of Radiation Oncology Biology Physics

IS - 2

ER -

Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this