Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study

For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan

Research output: Contribution to journalArticle

Abstract

Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years. Results: Based on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis. Conclusion: This histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalClinical and Experimental Nephrology
Volume23
Issue number3
DOIs
Publication statusPublished - 15-03-2019

Fingerprint

Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Cohort Studies
Kidney
Glomerular Filtration Rate
Biopsy
Histology
Survival Rate

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan (2019). Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. Clinical and Experimental Nephrology, 23(3), 387-394. https://doi.org/10.1007/s10157-018-1656-1
For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan. / Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. In: Clinical and Experimental Nephrology. 2019 ; Vol. 23, No. 3. pp. 387-394.
@article{a0223a932f1f40ae9b0a73386402670c,
title = "Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study",
abstract = "Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years. Results: Based on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis. Conclusion: This histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.",
author = "{For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan} and Kunihiro Yamagata and Joichi Usui and Michio Nagata and Hitoshi Sugiyama and Sada, {Ken ei} and Eri Muso and Masayoshi Harigai and Koichi Amano and Tatsuya Atsumi and Shouichi Fujimoto and Yukio Yuzawa and Masaki Kobayashi and Yukio Yuzawa and Takafumi Ito and Nobuhito Hirawa and Sakae Homma and Hiroaki Dobashi and Naotaka Tsuboi and Akihiro Ishizu and Yoshihiro Arimura and Hirofumi Makino and Seiichi Matsuo and Yoshinari Takasaki and Shogo Banno and Takahiko Sugihara and Yohko Murakawa and Hitoshi Hasegawa and Atsushi Komatsuda and Satoshi Ito and Takao Fujii and Atsushi Kawakami and Izaya Nakaya and Masahiro Yamamura and Masaaki Nakano and Kosaku Nitta and Makoto Ogura and Taio Naniwa and Shoichi Ozaki and Junichi Hirahashi and Noriyoshi Ogawa and Tatsuo Hosoya and Takashi Wada and Satoshi Horikoshi and Yasushi Kawaguchi and Taichi Hayashi and Masaharu Yoshida and Tsuyoshi Watanabe and Daijo Inaguma and Kazuhiko Tsuruya and Daijo Inaguma",
year = "2019",
month = "3",
day = "15",
doi = "10.1007/s10157-018-1656-1",
language = "English",
volume = "23",
pages = "387--394",
journal = "Clinical and Experimental Nephrology",
issn = "1342-1751",
publisher = "Springer Japan",
number = "3",

}

For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan 2019, 'Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study' Clinical and Experimental Nephrology, vol. 23, no. 3, pp. 387-394. https://doi.org/10.1007/s10157-018-1656-1

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. / For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan.

In: Clinical and Experimental Nephrology, Vol. 23, No. 3, 15.03.2019, p. 387-394.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study

AU - For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan

AU - Yamagata, Kunihiro

AU - Usui, Joichi

AU - Nagata, Michio

AU - Sugiyama, Hitoshi

AU - Sada, Ken ei

AU - Muso, Eri

AU - Harigai, Masayoshi

AU - Amano, Koichi

AU - Atsumi, Tatsuya

AU - Fujimoto, Shouichi

AU - Yuzawa, Yukio

AU - Kobayashi, Masaki

AU - Yuzawa, Yukio

AU - Ito, Takafumi

AU - Hirawa, Nobuhito

AU - Homma, Sakae

AU - Dobashi, Hiroaki

AU - Tsuboi, Naotaka

AU - Ishizu, Akihiro

AU - Arimura, Yoshihiro

AU - Makino, Hirofumi

AU - Matsuo, Seiichi

AU - Takasaki, Yoshinari

AU - Banno, Shogo

AU - Sugihara, Takahiko

AU - Murakawa, Yohko

AU - Hasegawa, Hitoshi

AU - Komatsuda, Atsushi

AU - Ito, Satoshi

AU - Fujii, Takao

AU - Kawakami, Atsushi

AU - Nakaya, Izaya

AU - Yamamura, Masahiro

AU - Nakano, Masaaki

AU - Nitta, Kosaku

AU - Ogura, Makoto

AU - Naniwa, Taio

AU - Ozaki, Shoichi

AU - Hirahashi, Junichi

AU - Ogawa, Noriyoshi

AU - Hosoya, Tatsuo

AU - Wada, Takashi

AU - Horikoshi, Satoshi

AU - Kawaguchi, Yasushi

AU - Hayashi, Taichi

AU - Yoshida, Masaharu

AU - Watanabe, Tsuyoshi

AU - Inaguma, Daijo

AU - Tsuruya, Kazuhiko

AU - Inaguma, Daijo

PY - 2019/3/15

Y1 - 2019/3/15

N2 - Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years. Results: Based on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis. Conclusion: This histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.

AB - Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis. Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Based on the EUVAS-proposed histopathological classification and some histological parameters, we statistically evaluated renal survival and the comparison of renal function for 2 years. Results: Based on the histopathological classification, the largest number of biopsy samples belonged to the Focal class, followed by the Mixed, Crescentic, and Sclerotic classes (n = 30, 19, 10, 8, respectively). Although the number of events might be too low (four patients with renal death) to make this conclusion, the Focal and Mixed classes had higher renal-survival rates compared to the others in the renal-survival curve. Comparing renal function among all classes, the estimated glomerular filtration rate (eGFR) throughout 2-year follow-up period was significantly higher in the Focal class compared to the other 3 classes. The eGFR-values in the Crescentic, Mixed, and Sclerotic classes increased with time. Based on both combined results, the Focal class could be the best prognosis. Conclusion: This histopathological classification was valuable for both the stratification of renal function and the estimation of partial renal survival during 2-year follow-up in ANCA-associated glomerulonephritis.

UR - http://www.scopus.com/inward/record.url?scp=85055313859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055313859&partnerID=8YFLogxK

U2 - 10.1007/s10157-018-1656-1

DO - 10.1007/s10157-018-1656-1

M3 - Article

VL - 23

SP - 387

EP - 394

JO - Clinical and Experimental Nephrology

JF - Clinical and Experimental Nephrology

SN - 1342-1751

IS - 3

ER -

For the Research Committee of Intractable Renal Disease and the Research Committee of Intractable Vasculitis Syndrome of the Ministry of Health, Labour, and Welfare of Japan. Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study. Clinical and Experimental Nephrology. 2019 Mar 15;23(3):387-394. https://doi.org/10.1007/s10157-018-1656-1