TY - JOUR
T1 - History of cholelithiasis and the risk of prostate cancer
T2 - The Ohsaki Cohort Study
AU - Li, Qiang
AU - Kuriyama, Shinichi
AU - Kakizaki, Masako
AU - Yan, Hong
AU - Nagai, Masato
AU - Sugawara, Yumi
AU - Ohmori-Matsuda, Kaori
AU - Hozawa, Atsushi
AU - Nishino, Yoshikazu
AU - Tsuji, Ichiro
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - An association between cholelithiasis and prostate cancer has been reported sporadically in previous case-control and experimental studies, suggesting that cholesterol may play a promotional role in prostate cancer development and progression. However, this relationship remains poorly understood, and population evidence based on a strict study design is needed. The authors examined the history of cholelithiasis and the development of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were ascertained among 22,458 Japanese men. Baseline information, including history of cholelithiasis, was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed that patients with a history of cholelithiasis had a higher risk of prostate cancer with a multivariate adjusted HR of 1.72 (95% CI: 1.12 2.66), and especially for advanced prostate cancer, the corresponding value was 2.29 (95% CI: 1.21 4.35). The associations were robust after adjustment for different potential confounders. This population-based prospective cohort study indicates that a history of cholelithiasis is associated with an increased incidence of prostate cancer.
AB - An association between cholelithiasis and prostate cancer has been reported sporadically in previous case-control and experimental studies, suggesting that cholesterol may play a promotional role in prostate cancer development and progression. However, this relationship remains poorly understood, and population evidence based on a strict study design is needed. The authors examined the history of cholelithiasis and the development of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were ascertained among 22,458 Japanese men. Baseline information, including history of cholelithiasis, was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed that patients with a history of cholelithiasis had a higher risk of prostate cancer with a multivariate adjusted HR of 1.72 (95% CI: 1.12 2.66), and especially for advanced prostate cancer, the corresponding value was 2.29 (95% CI: 1.21 4.35). The associations were robust after adjustment for different potential confounders. This population-based prospective cohort study indicates that a history of cholelithiasis is associated with an increased incidence of prostate cancer.
KW - Cholelithiasis
KW - Incidence
KW - Japan
KW - Prospective studies
KW - Prostatic neoplasms
UR - http://www.scopus.com/inward/record.url?scp=78349272702&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78349272702&partnerID=8YFLogxK
U2 - 10.1002/ijc.25303
DO - 10.1002/ijc.25303
M3 - Article
C2 - 20209501
AN - SCOPUS:78349272702
SN - 0020-7136
VL - 128
SP - 185
EP - 191
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 1
ER -