History of diabetes mellitus and the risk of prostate cancer: The Ohsaki Cohort Study

Qiang Li, Shinichi Kuriyama, Masako Kakizaki, Hong Yan, Toshimasa Sone, Masato Nagai, Yumi Sugawara, Kaori Ohmori-Matsuda, Atsushi Hozawa, Yoshikazu Nishino, Ichiro Tsuji

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective The association between diabetes mellitus and the risk of prostate cancer has been tested in previous prospective cohort studies in western populations. However, no evidence from cohort studies is available for Asian populations, whose lifestyle is very different from that of westerners. Methods The authors examined the relationship between diabetes mellitus and the risk of prostate cancer in the Ohsaki cohort followed from 1995 to 2003, in which 230 new cases of prostate cancer were identified among 22,458 Japanese men. Baseline information including diabetes mellitus status was collected using a self-administered questionnaire. The Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results Although a history of diabetes mellitus was not associated with the risk of total prostate cancer in this population, after stratification based on the clinical stage of prostate cancer, patients with diabetes mellitus showed a higher risk of advanced prostate cancer with a multivariate adjusted HR = 1.89 (95% CI: 1.02-3.50). The relationship remained robust when we excluded from the analysis cases arising in the first 2 years. Conclusion This population-based prospective cohort study indicates that a history of diabetes mellitus is associated with an increased incidence of advanced prostate cancer.

Original languageEnglish
Pages (from-to)1025-1032
Number of pages8
JournalCancer Causes and Control
Volume21
Issue number7
DOIs
Publication statusPublished - 01-07-2010

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'History of diabetes mellitus and the risk of prostate cancer: The Ohsaki Cohort Study'. Together they form a unique fingerprint.

  • Cite this

    Li, Q., Kuriyama, S., Kakizaki, M., Yan, H., Sone, T., Nagai, M., Sugawara, Y., Ohmori-Matsuda, K., Hozawa, A., Nishino, Y., & Tsuji, I. (2010). History of diabetes mellitus and the risk of prostate cancer: The Ohsaki Cohort Study. Cancer Causes and Control, 21(7), 1025-1032. https://doi.org/10.1007/s10552-010-9530-9