History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu; Tetsuya Tsukamoto; Tsutomu Mizoshita

doi:10.1007/4-431-27713-7_1

History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu, Tetsuya Tsukamoto, Tsutomu Mizoshita

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

Original language	English
Title of host publication	The Diversity of Gastric Carcinoma
Subtitle of host publication	Pathogenesis, Diagnosis, and Therapy
Publisher	Springer Tokyo
Pages	3-28
Number of pages	26
ISBN (Print)	443121139X, 9784431211396
DOIs	https://doi.org/10.1007/4-431-27713-7_1
Publication status	Published - 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Medicine

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/4-431-27713-7_1

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T1 - History of gastric carcinoma research in Japan

T2 - Basic aspects

AU - Tatematsu, Masae

AU - Tsukamoto, Tetsuya

AU - Mizoshita, Tsutomu

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AB - Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

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SN - 9784431211396

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BT - The Diversity of Gastric Carcinoma

PB - Springer Tokyo

ER -

History of gastric carcinoma research in Japan: Basic aspects

Abstract

All Science Journal Classification (ASJC) codes

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