History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu, Tetsuya Tsukamoto, Tsutomu Mizoshita

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)


Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

Original languageEnglish
Title of host publicationThe Diversity of Gastric Carcinoma
Subtitle of host publicationPathogenesis, Diagnosis, and Therapy
PublisherSpringer Tokyo
Number of pages26
ISBN (Print)443121139X, 9784431211396
Publication statusPublished - 01-12-2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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