History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu; Tetsuya Tsukamoto; Tsutomu Mizoshita

doi:10.1007/4-431-27713-7_1

History of gastric carcinoma research in Japan: Basic aspects

Masae Tatematsu
, Tetsuya Tsukamoto
, Tsutomu Mizoshita

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Citations (Scopus)

Abstract

Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

Original language	English
Title of host publication	The Diversity of Gastric Carcinoma
Subtitle of host publication	Pathogenesis, Diagnosis, and Therapy
Publisher	Springer Tokyo
Pages	3-28
Number of pages	26
ISBN (Print)	443121139X, 9784431211396
DOIs	https://doi.org/10.1007/4-431-27713-7_1
Publication status	Published - 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1007/4-431-27713-7_1

Cite this

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abstract = "Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.",

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doi = "10.1007/4-431-27713-7\_1",

language = "English",

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T1 - History of gastric carcinoma research in Japan

T2 - Basic aspects

AU - Tatematsu, Masae

AU - Tsukamoto, Tetsuya

AU - Mizoshita, Tsutomu

PY - 2005

Y1 - 2005

N2 - Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

AB - Gastric cancers develop from single cells, based on data from clonality analysis in C3H/HeN → BALB/c chimeric mice. We can conclude that IM is important not as a precancerous lesion but as a paracancerous cord from such studies of clonality of gastric cancers and of phenotypic expression of each intestinal metaplastic or stomach cancer cell. Intestinalization progresses from G, through GI, to I types in noncancerous and cancerous tissue independently, accompanied by homeotic transformation of underlying control factors. H. pylori is not an initiator, but rather a strong promoter in gastric carcinogenesis, and its eradication, together with reduction in salt intake, might effectively prevent gastric cancer development.

UR - https://www.scopus.com/pages/publications/33645309715

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U2 - 10.1007/4-431-27713-7_1

DO - 10.1007/4-431-27713-7_1

M3 - Chapter

AN - SCOPUS:33645309715

SN - 443121139X

SN - 9784431211396

SP - 3

EP - 28

BT - The Diversity of Gastric Carcinoma

PB - Springer Tokyo

ER -

History of gastric carcinoma research in Japan: Basic aspects

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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