HLA-A alleles and the risk of cervical squamous cell carcinoma in Japanese women

Satoyo Hosono, Takakazu Kawase, Keitaro Matsuo, Miki Watanabe, Hiroaki Kajiyama, Kaoru Hirose, Takeshi Suzuki, Kumiko Kidokoro, Hidemi Ito, Toru Nakanishi, Yasushi Yatabe, Nobuyuki Hamajima, Fumitaka Kikkawa, Kazuo Tajima, Hideo Tanaka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: We conducted a case-control study to examine the relationship between human leukocyte antigen-A (HLA-A) allele polymorphism and the pathogenesis of cervical neoplasia among Japanese women. Methods: A total of 119 patients with invasive cervical squamous cell carcinoma were compared to 119 age- and menopausal status-matched non-cancer controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of HLA-A alleles on cervical cancer risk was evaluated by unconditional logistic regression models. Results: The frequency of HLA-A*0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A*0206 and cervical cancer risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for HLA-A*2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A*0206 was significantly associated with reduced cervical cancer risk (corrected P = 0.036). Furthermore, the inverse association between A*0206 and cervical cancer risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89). Conclusions: There was an inverse association between HLA-A*0206 and cervical cancer risk among Japanese women, which suggests that HLA-A polymorphism influences cervical cancer risk. Further investigation in other populations is thus warranted.

Original languageEnglish
Pages (from-to)295-301
Number of pages7
JournalJournal of epidemiology
Volume20
Issue number4
DOIs
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Epidemiology

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