HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Nahoko Kaniwa; Yoshiro Saito; Michiko Aihara; Kayoko Matsunaga; Masahiro Tohkin; Kouichi Kurose; Hirokazu Furuya; Yukitoshi Takahashi; Masaaki Muramatsu; Shigeru Kinoshita; Masamichi Abe; Hiroko Ikeda; Mariko Kashiwagi; Yixuan Song; Mayumi Ueta; Chie Sotozono; Zenro Ikezawa; Ryuichi Hasegawa

doi:10.1111/j.1528-1167.2010.02766.x

HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Nahoko Kaniwa, Yoshiro Saito, Michiko Aihara, Kayoko Matsunaga, Masahiro Tohkin, Kouichi Kurose, Hirokazu Furuya, Yukitoshi Takahashi, Masaaki Muramatsu, Shigeru Kinoshita, Masamichi Abe, Hiroko Ikeda, Mariko Kashiwagi, Yixuan Song, Mayumi Ueta, Chie Sotozono, Zenro Ikezawa, Ryuichi Hasegawa

integrative medical science for allergic disease

Research output: Contribution to journal › Article › peer-review

214 Citations (Scopus)

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.

Original language	English
Pages (from-to)	2461-2465
Number of pages	5
Journal	Epilepsia
Volume	51
Issue number	12
DOIs	https://doi.org/10.1111/j.1528-1167.2010.02766.x
Publication status	Published - 12-2010

All Science Journal Classification (ASJC) codes

Neurology
Clinical Neurology

Access to Document

10.1111/j.1528-1167.2010.02766.x

Cite this

Kaniwa, N., Saito, Y., Aihara, M., Matsunaga, K., Tohkin, M., Kurose, K., Furuya, H., Takahashi, Y., Muramatsu, M., Kinoshita, S., Abe, M., Ikeda, H., Kashiwagi, M., Song, Y., Ueta, M., Sotozono, C., Ikezawa, Z., & Hasegawa, R. (2010). HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia, 51(12), 2461-2465. https://doi.org/10.1111/j.1528-1167.2010.02766.x

@article{cc6887d27a124aa3a5d108eb07e001b9,

title = "HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients",

abstract = "Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.",

author = "Nahoko Kaniwa and Yoshiro Saito and Michiko Aihara and Kayoko Matsunaga and Masahiro Tohkin and Kouichi Kurose and Hirokazu Furuya and Yukitoshi Takahashi and Masaaki Muramatsu and Shigeru Kinoshita and Masamichi Abe and Hiroko Ikeda and Mariko Kashiwagi and Yixuan Song and Mayumi Ueta and Chie Sotozono and Zenro Ikezawa and Ryuichi Hasegawa",

year = "2010",

month = dec,

doi = "10.1111/j.1528-1167.2010.02766.x",

language = "English",

volume = "51",

pages = "2461--2465",

journal = "Epilepsia",

issn = "0013-9580",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "12",

}

Kaniwa, N, Saito, Y, Aihara, M, Matsunaga, K, Tohkin, M, Kurose, K, Furuya, H, Takahashi, Y, Muramatsu, M, Kinoshita, S, Abe, M, Ikeda, H, Kashiwagi, M, Song, Y, Ueta, M, Sotozono, C, Ikezawa, Z & Hasegawa, R 2010, 'HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients', Epilepsia, vol. 51, no. 12, pp. 2461-2465. https://doi.org/10.1111/j.1528-1167.2010.02766.x

TY - JOUR

T1 - HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

AU - Kaniwa, Nahoko

AU - Saito, Yoshiro

AU - Aihara, Michiko

AU - Matsunaga, Kayoko

AU - Tohkin, Masahiro

AU - Kurose, Kouichi

AU - Furuya, Hirokazu

AU - Takahashi, Yukitoshi

AU - Muramatsu, Masaaki

AU - Kinoshita, Shigeru

AU - Abe, Masamichi

AU - Ikeda, Hiroko

AU - Kashiwagi, Mariko

AU - Song, Yixuan

AU - Ueta, Mayumi

AU - Sotozono, Chie

AU - Ikezawa, Zenro

AU - Hasegawa, Ryuichi

PY - 2010/12

Y1 - 2010/12

N2 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.

AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.

UR - http://www.scopus.com/inward/record.url?scp=78650007285&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650007285&partnerID=8YFLogxK

U2 - 10.1111/j.1528-1167.2010.02766.x

DO - 10.1111/j.1528-1167.2010.02766.x

M3 - Article

C2 - 21204807

AN - SCOPUS:78650007285

SN - 0013-9580

VL - 51

SP - 2461

EP - 2465

JO - Epilepsia

JF - Epilepsia

IS - 12

ER -

HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this