TY - JOUR
T1 - HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
AU - Kaniwa, Nahoko
AU - Saito, Yoshiro
AU - Aihara, Michiko
AU - Matsunaga, Kayoko
AU - Tohkin, Masahiro
AU - Kurose, Kouichi
AU - Furuya, Hirokazu
AU - Takahashi, Yukitoshi
AU - Muramatsu, Masaaki
AU - Kinoshita, Shigeru
AU - Abe, Masamichi
AU - Ikeda, Hiroko
AU - Kashiwagi, Mariko
AU - Song, Yixuan
AU - Ueta, Mayumi
AU - Sotozono, Chie
AU - Ikezawa, Zenro
AU - Hasegawa, Ryuichi
PY - 2010/12
Y1 - 2010/12
N2 - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.
AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 with carbamazepine-induced SJS/TEN have been found in Han Chinese patients. These associations have been confirmed in several Asian populations, excluding Japanese. SJS patients carrying HLA-B*1508, HLA-B*1511, or HLA-B*1521, which are members of the HLA-B75 type along with HLA-B*1502, were detected in studies in India and Thailand. In the current study, we genotyped the HLA-B locus from 14 Japanese typical and atypical SJS/TEN patients in whom carbamazepine was considered to be involved in the onset of adverse reactions. Although there were no HLA-B*1502 carriers, four patients had HLA-B*1511. Our data suggest that HLA-B*1511, a member of HLA-B75, is a risk factor for carbamazepine- induced SJS/TEN in Japanese.
KW - HLA-B1502
KW - HLA-B75
KW - Serotype
UR - https://www.scopus.com/pages/publications/78650007285
UR - https://www.scopus.com/pages/publications/78650007285#tab=citedBy
U2 - 10.1111/j.1528-1167.2010.02766.x
DO - 10.1111/j.1528-1167.2010.02766.x
M3 - Article
C2 - 21204807
AN - SCOPUS:78650007285
SN - 0013-9580
VL - 51
SP - 2461
EP - 2465
JO - Epilepsia
JF - Epilepsia
IS - 12
ER -