HLA-DQ gene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection

Yuka Ochi, Senju Hashimoto, Naoto Kawabe, Michihito Murao, Takuji Nakano, Toshiki Kan, Kazunori Nakaoka, Masashi Ohki, Takamitsu Kurashita, Tomoki Takamura, Sayuri Nomura, Toru Nishikawa, Aiko Fukui, Keisuke Osakabe, Naohiro Ichino, Kentaro Yoshioka

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5 Citations (Scopus)

Abstract

Aim: Genome-wide association studies have revealed that single nucleotide polymorphism (SNP) of human leukocyte antigen (HLA)-DQ is associated with the clearance of hepatitis B surface antigen (HBsAg) in acute hepatitis B virus (HBV) infection. We examined the effects of SNPs on the development of hepatocellular carcinoma (HCC) and markers of HBV in chronic HBV infection. Methods: The SNPs of HLA-DQ (rs2856718 and rs7453920) were determined in 299 patients with chronic HBV infection. Results: In 224 hepatitis B e antigen (HBeAg)-negative patients, those with rs2856718 genotype AG + GG had significantly lower hepatitis B core-related antigen levels (P = 0.0184), less frequent treatment with nucleotide/nucleoside analogs (NAs) (P = 0.0433), and less frequent HCC development (P = 0.0256) than those with genotype AA. Multivariate analysis selected age (P = 0.0460), platelet count (P = 0.0481), γ-glutamyl transpeptidase (P = 0.0030), and nucleotide/nucleoside analog treatment (P = 0.0003) as factors independently associated with HCC development. HBeAg-negative patients with rs7453920 genotype GG had significantly lower HBsAg levels (P < 0.0001), a higher prevalence of HBV genotype C (P = 0.0063), and a lower prevalence of the wild-type basal core promoter region (P = 0.0045) than those with genotype AA + AG. Multivariate analysis selected age (P < 0.0001), platelet count (P = 0.0021), HBV DNA levels (P = 0.0314), wild type of precore region (P = 0.0015), and rs7453920 (P < 0.0001) as factors independently associated with HBsAg levels. Conclusion: This study revealed an association between rs2856718 and HCC development and an association between rs7453920 and HBsAg levels.

Original languageEnglish
Pages (from-to)755-766
Number of pages12
JournalHepatology Research
Volume47
Issue number8
DOIs
Publication statusPublished - 01-07-2017

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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    Ochi, Y., Hashimoto, S., Kawabe, N., Murao, M., Nakano, T., Kan, T., Nakaoka, K., Ohki, M., Kurashita, T., Takamura, T., Nomura, S., Nishikawa, T., Fukui, A., Osakabe, K., Ichino, N., & Yoshioka, K. (2017). HLA-DQ gene polymorphisms are associated with hepatocellular carcinoma and hepatitis B surface antigen in chronic hepatitis B virus infection. Hepatology Research, 47(8), 755-766. https://doi.org/10.1111/hepr.12812