HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits

Ayami Saga, Hanayuki Okura, Mayumi Soeda, Junko Tani, Yuichi Fumimoto, Hiroshi Komoda, Mariko Moriyama, Hiroyuki Moriyama, Shizuya Yamashita, Akihiro Ichinose, Takashi Daimon, Takao Hayakawa, Akifumi Matsuyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume412
Issue number1
DOIs
Publication statusPublished - 19-08-2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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