HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits

Ayami Saga; Hanayuki Okura; Mayumi Soeda; Junko Tani; Yuichi Fumimoto; Hiroshi Komoda; Mariko Moriyama; Hiroyuki Moriyama; Shizuya Yamashita; Akihiro Ichinose; Takashi Daimon; Takao Hayakawa; Akifumi Matsuyama

doi:10.1016/j.bbrc.2011.07.035

HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits

Ayami Saga
, Hanayuki Okura
, Mayumi Soeda
, Junko Tani
, Yuichi Fumimoto
, Hiroshi Komoda
, Mariko Moriyama
, Hiroyuki Moriyama
, Shizuya Yamashita
, Akihiro Ichinose
, Takashi Daimon
, Takao Hayakawa
, Akifumi Matsuyama

International Center for Cell and Gene Therapy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.

Original language	English
Pages (from-to)	50-54
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	412
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2011.07.035
Publication status	Published - 19-08-2011

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/j.bbrc.2011.07.035

Cite this

Saga, A., Okura, H., Soeda, M., Tani, J., Fumimoto, Y., Komoda, H., Moriyama, M., Moriyama, H., Yamashita, S., Ichinose, A., Daimon, T., Hayakawa, T., & Matsuyama, A. (2011). HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits. Biochemical and Biophysical Research Communications, 412(1), 50-54. https://doi.org/10.1016/j.bbrc.2011.07.035

@article{0e9ee94aaa2b4881832a92d995774b65,

title = "HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits",

abstract = "Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.",

author = "Ayami Saga and Hanayuki Okura and Mayumi Soeda and Junko Tani and Yuichi Fumimoto and Hiroshi Komoda and Mariko Moriyama and Hiroyuki Moriyama and Shizuya Yamashita and Akihiro Ichinose and Takashi Daimon and Takao Hayakawa and Akifumi Matsuyama",

note = "Funding Information: This study was supported in part by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO), and Kobe Translational Research Cluster , the Knowledge Cluster Initiative , Ministry of Education, Culture, Sports, Science and Technology (MEXT).",

year = "2011",

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doi = "10.1016/j.bbrc.2011.07.035",

language = "English",

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Saga, A, Okura, H, Soeda, M, Tani, J, Fumimoto, Y, Komoda, H, Moriyama, M, Moriyama, H, Yamashita, S, Ichinose, A, Daimon, T, Hayakawa, T & Matsuyama, A 2011, 'HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits', Biochemical and Biophysical Research Communications, vol. 412, no. 1, pp. 50-54. https://doi.org/10.1016/j.bbrc.2011.07.035

HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits. / Saga, Ayami; Okura, Hanayuki; Soeda, Mayumi et al.
In: Biochemical and Biophysical Research Communications, Vol. 412, No. 1, 19.08.2011, p. 50-54.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits

AU - Saga, Ayami

AU - Okura, Hanayuki

AU - Soeda, Mayumi

AU - Tani, Junko

AU - Fumimoto, Yuichi

AU - Komoda, Hiroshi

AU - Moriyama, Mariko

AU - Moriyama, Hiroyuki

AU - Yamashita, Shizuya

AU - Ichinose, Akihiro

AU - Daimon, Takashi

AU - Hayakawa, Takao

AU - Matsuyama, Akifumi

N1 - Funding Information: This study was supported in part by the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO), and Kobe Translational Research Cluster , the Knowledge Cluster Initiative , Ministry of Education, Culture, Sports, Science and Technology (MEXT).

PY - 2011/8/19

Y1 - 2011/8/19

N2 - Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.

AB - Familial hypercholesterolemia (FH) is an autosomal codominant disease characterized by high concentrations of proatherogenic lipoproteins secondary to deficiency in low-density lipoprotein (LDL) receptor. We reported recently the use of in situ stem cell therapy of human adipose tissue-derived multilineage progenitor cells (hADMPCs) in lowering serum total cholesterol in the homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model of homozygous FH. Here we demonstrate that pravastatin, an HMG-CoA reductase inhibitor, augmented the cholesterol-lowering effect of transplanted hADMPCs and enhanced LDL clearance in homozygous WHHL rabbit. The results suggest the potential beneficial effects of in situ stem cell therapy in concert with appropriately selected pharmaceutical agents, in regenerative medicine.

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M3 - Article

C2 - 21806964

AN - SCOPUS:80051798604

SN - 0006-291X

VL - 412

SP - 50

EP - 54

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 1

ER -

HMG-CoA reductase inhibitor augments the serum total cholesterol-lowering effect of human adipose tissue-derived multilineage progenitor cells in hyperlipidemic homozygous Watanabe rabbits

Abstract

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