Homozygous TRPV1 315C Influences the Susceptibility to Functional Dyspepsia

Tomomitsu Tahara; Tomoyuki Shibata; Masakatsu Nakamura; Hiromi Yamashita; Daisuke Yoshioka; Ichiro Hirata; Tomiyasu Arisawa

doi:10.1097/MCG.0b013e3181b5745e

Homozygous TRPV1 315C Influences the Susceptibility to Functional Dyspepsia

Tomomitsu Tahara, Tomoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Ichiro Hirata, Tomiyasu Arisawa

Gastroenterology

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily. The G315C polymorphism affects the TRPV1 gene and alters its protein level. We aimed to investigate the effect of TRPV1 G315C polymorphism on functional dyspepsia (FD) in a Japanese population.

Original language	English
Pages (from-to)	e1-e7
Journal	Journal of Clinical Gastroenterology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1097/MCG.0b013e3181b5745e
Publication status	Published - 01-2010

All Science Journal Classification (ASJC) codes

Gastroenterology

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10.1097/MCG.0b013e3181b5745e

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abstract = "Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily. The G315C polymorphism affects the TRPV1 gene and alters its protein level. We aimed to investigate the effect of TRPV1 G315C polymorphism on functional dyspepsia (FD) in a Japanese population.",

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AU - Tahara, Tomomitsu

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AU - Nakamura, Masakatsu

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Hirata, Ichiro

AU - Arisawa, Tomiyasu

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AB - Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily. The G315C polymorphism affects the TRPV1 gene and alters its protein level. We aimed to investigate the effect of TRPV1 G315C polymorphism on functional dyspepsia (FD) in a Japanese population.

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Homozygous TRPV1 315C Influences the Susceptibility to Functional Dyspepsia

Abstract

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