How did the primordial T cell receptor and MHC molecules function initially?

Yoshikazu Kurosawa, Keiichiro Hashimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Two genes, designated Trsc-UAA and Trsc-UBA, which encode highly polymorphic major histocompatibility complex (MHC) class I molecules in the shark Triakis scyllia were isolated. The identification of these genes indicates that the classical MHC class I was already established at the level of elasmobranchs during animal evolution. At the emergence of the MHC/T cell receptor recognition system, the number of genes for T cell receptors (TCR) must have been just one. In this brief review, the way in which a small number of TCR could have recognized MHC-oligopeptide complexes initially, based on recent progress in the phylogenetic analysis of the immune systems in primitive vertebrates, is discussed.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalImmunology and Cell Biology
Volume75
Issue number2
DOIs
Publication statusPublished - 01-01-1997

Fingerprint

T-Cell Antigen Receptor
Major Histocompatibility Complex
Elasmobranchii
T-Cell Receptor Genes
Sharks
Oligopeptides
Systems Analysis
Genes
Vertebrates
Immune System

All Science Journal Classification (ASJC) codes

  • Immunology
  • Cell Biology

Cite this

@article{36bc56a9a09f40dabc2970ab660206f7,
title = "How did the primordial T cell receptor and MHC molecules function initially?",
abstract = "Two genes, designated Trsc-UAA and Trsc-UBA, which encode highly polymorphic major histocompatibility complex (MHC) class I molecules in the shark Triakis scyllia were isolated. The identification of these genes indicates that the classical MHC class I was already established at the level of elasmobranchs during animal evolution. At the emergence of the MHC/T cell receptor recognition system, the number of genes for T cell receptors (TCR) must have been just one. In this brief review, the way in which a small number of TCR could have recognized MHC-oligopeptide complexes initially, based on recent progress in the phylogenetic analysis of the immune systems in primitive vertebrates, is discussed.",
author = "Yoshikazu Kurosawa and Keiichiro Hashimoto",
year = "1997",
month = "1",
day = "1",
doi = "10.1038/icb.1997.28",
language = "English",
volume = "75",
pages = "193--196",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "Nature Publishing Group",
number = "2",

}

How did the primordial T cell receptor and MHC molecules function initially? / Kurosawa, Yoshikazu; Hashimoto, Keiichiro.

In: Immunology and Cell Biology, Vol. 75, No. 2, 01.01.1997, p. 193-196.

Research output: Contribution to journalArticle

TY - JOUR

T1 - How did the primordial T cell receptor and MHC molecules function initially?

AU - Kurosawa, Yoshikazu

AU - Hashimoto, Keiichiro

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Two genes, designated Trsc-UAA and Trsc-UBA, which encode highly polymorphic major histocompatibility complex (MHC) class I molecules in the shark Triakis scyllia were isolated. The identification of these genes indicates that the classical MHC class I was already established at the level of elasmobranchs during animal evolution. At the emergence of the MHC/T cell receptor recognition system, the number of genes for T cell receptors (TCR) must have been just one. In this brief review, the way in which a small number of TCR could have recognized MHC-oligopeptide complexes initially, based on recent progress in the phylogenetic analysis of the immune systems in primitive vertebrates, is discussed.

AB - Two genes, designated Trsc-UAA and Trsc-UBA, which encode highly polymorphic major histocompatibility complex (MHC) class I molecules in the shark Triakis scyllia were isolated. The identification of these genes indicates that the classical MHC class I was already established at the level of elasmobranchs during animal evolution. At the emergence of the MHC/T cell receptor recognition system, the number of genes for T cell receptors (TCR) must have been just one. In this brief review, the way in which a small number of TCR could have recognized MHC-oligopeptide complexes initially, based on recent progress in the phylogenetic analysis of the immune systems in primitive vertebrates, is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0030891034&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030891034&partnerID=8YFLogxK

U2 - 10.1038/icb.1997.28

DO - 10.1038/icb.1997.28

M3 - Article

C2 - 9107575

AN - SCOPUS:0030891034

VL - 75

SP - 193

EP - 196

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

SN - 0818-9641

IS - 2

ER -