How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment: Comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population

Makoto Tsujita, Norihiko Goto, Takayuki Yamamoto, Takahisa Hiramitsu, Koji Nanmoku, Daijo Inaguma, Asami Takeda, Takaaki Kobayashi, Yoshihiro Tominaga, Kunio Morozumi, Kazuharu Uchida, Yoshihiko Watarai

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Abstract

Background: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. Methods: This study included 73 patients who had undergone renal transplantation at Nagoya Daini Red Cross Hospital at least 6 months previously and had stable renal function for >3 months. Glomerular filtration rates (GFRs) were measured by inulin clearance (mGFR) and compared with estimated cystatin C-based GFRs (eGFRcys), estimated creatinine-based GFRs (eGFRcre) and their average values (eGFRave). Results: mGFR was 43.3 ± 14.1 mL/min/1.73 m2, eGFRcre was 39.6 ± 11.7, eGFRcys was 56.0 ± 17.1, and eGFRave was 47.8 ± 13.7 mL/min/1.73 m2. Serum cystatin C was 1.39 ± 0.37 mg/L and serum creatinine was 1.58 ± 0.51 mg/dL. The correlation coefficients between mGFR and eGFRcre, eGFRcys, and eGFRave were 0.768, 0.831, and 0.841, respectively (P < 0.001, for all).The intraclass correlation coefficients were 0.754, 0.816, and 0.840, respectively (P < 0.001, for all).The mean differences between measured and estimated GFR values were 3.74 mL/min/1.73 m2 with a root-mean square error (RMSE) of 9.06 for eGFRcre, +12.64 with RMSE of 9.48 for eGFRcys, and +4.45 with RMSE of 7.86 for eGFRave. Bland-Altman plots showed that eGFRcys overestimated GFR values compared with mGFR values in most cases and that eGFRave overestimated GFR values in 53 of 73 cases, whereas eGFRcre underestimated the values in 53 of 73 cases. Conclusion: eGFRave may be the best marker to estimate kidney function in Japanese renal transplant recipients with mildly reduced or normal kidney function.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalClinical and Experimental Nephrology
Volume18
Issue number1
DOIs
Publication statusPublished - 01-01-2014
Externally publishedYes

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Cystatin C
Glomerular Filtration Rate
Creatinine
Kidney
Population
Kidney Transplantation
Red Cross
Inulin
Serum
Transplant Recipients
Japan

All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Physiology (medical)

Cite this

Tsujita, Makoto ; Goto, Norihiko ; Yamamoto, Takayuki ; Hiramitsu, Takahisa ; Nanmoku, Koji ; Inaguma, Daijo ; Takeda, Asami ; Kobayashi, Takaaki ; Tominaga, Yoshihiro ; Morozumi, Kunio ; Uchida, Kazuharu ; Watarai, Yoshihiko. / How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment : Comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population. In: Clinical and Experimental Nephrology. 2014 ; Vol. 18, No. 1. pp. 130-134.
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abstract = "Background: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. Methods: This study included 73 patients who had undergone renal transplantation at Nagoya Daini Red Cross Hospital at least 6 months previously and had stable renal function for >3 months. Glomerular filtration rates (GFRs) were measured by inulin clearance (mGFR) and compared with estimated cystatin C-based GFRs (eGFRcys), estimated creatinine-based GFRs (eGFRcre) and their average values (eGFRave). Results: mGFR was 43.3 ± 14.1 mL/min/1.73 m2, eGFRcre was 39.6 ± 11.7, eGFRcys was 56.0 ± 17.1, and eGFRave was 47.8 ± 13.7 mL/min/1.73 m2. Serum cystatin C was 1.39 ± 0.37 mg/L and serum creatinine was 1.58 ± 0.51 mg/dL. The correlation coefficients between mGFR and eGFRcre, eGFRcys, and eGFRave were 0.768, 0.831, and 0.841, respectively (P < 0.001, for all).The intraclass correlation coefficients were 0.754, 0.816, and 0.840, respectively (P < 0.001, for all).The mean differences between measured and estimated GFR values were 3.74 mL/min/1.73 m2 with a root-mean square error (RMSE) of 9.06 for eGFRcre, +12.64 with RMSE of 9.48 for eGFRcys, and +4.45 with RMSE of 7.86 for eGFRave. Bland-Altman plots showed that eGFRcys overestimated GFR values compared with mGFR values in most cases and that eGFRave overestimated GFR values in 53 of 73 cases, whereas eGFRcre underestimated the values in 53 of 73 cases. Conclusion: eGFRave may be the best marker to estimate kidney function in Japanese renal transplant recipients with mildly reduced or normal kidney function.",
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How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment : Comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population. / Tsujita, Makoto; Goto, Norihiko; Yamamoto, Takayuki; Hiramitsu, Takahisa; Nanmoku, Koji; Inaguma, Daijo; Takeda, Asami; Kobayashi, Takaaki; Tominaga, Yoshihiro; Morozumi, Kunio; Uchida, Kazuharu; Watarai, Yoshihiko.

In: Clinical and Experimental Nephrology, Vol. 18, No. 1, 01.01.2014, p. 130-134.

Research output: Contribution to journalArticle

TY - JOUR

T1 - How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment

T2 - Comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population

AU - Tsujita, Makoto

AU - Goto, Norihiko

AU - Yamamoto, Takayuki

AU - Hiramitsu, Takahisa

AU - Nanmoku, Koji

AU - Inaguma, Daijo

AU - Takeda, Asami

AU - Kobayashi, Takaaki

AU - Tominaga, Yoshihiro

AU - Morozumi, Kunio

AU - Uchida, Kazuharu

AU - Watarai, Yoshihiko

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. Methods: This study included 73 patients who had undergone renal transplantation at Nagoya Daini Red Cross Hospital at least 6 months previously and had stable renal function for >3 months. Glomerular filtration rates (GFRs) were measured by inulin clearance (mGFR) and compared with estimated cystatin C-based GFRs (eGFRcys), estimated creatinine-based GFRs (eGFRcre) and their average values (eGFRave). Results: mGFR was 43.3 ± 14.1 mL/min/1.73 m2, eGFRcre was 39.6 ± 11.7, eGFRcys was 56.0 ± 17.1, and eGFRave was 47.8 ± 13.7 mL/min/1.73 m2. Serum cystatin C was 1.39 ± 0.37 mg/L and serum creatinine was 1.58 ± 0.51 mg/dL. The correlation coefficients between mGFR and eGFRcre, eGFRcys, and eGFRave were 0.768, 0.831, and 0.841, respectively (P < 0.001, for all).The intraclass correlation coefficients were 0.754, 0.816, and 0.840, respectively (P < 0.001, for all).The mean differences between measured and estimated GFR values were 3.74 mL/min/1.73 m2 with a root-mean square error (RMSE) of 9.06 for eGFRcre, +12.64 with RMSE of 9.48 for eGFRcys, and +4.45 with RMSE of 7.86 for eGFRave. Bland-Altman plots showed that eGFRcys overestimated GFR values compared with mGFR values in most cases and that eGFRave overestimated GFR values in 53 of 73 cases, whereas eGFRcre underestimated the values in 53 of 73 cases. Conclusion: eGFRave may be the best marker to estimate kidney function in Japanese renal transplant recipients with mildly reduced or normal kidney function.

AB - Background: With the recent increase in renal transplantations in Japan, accurate assessment of renal function is required. Methods: This study included 73 patients who had undergone renal transplantation at Nagoya Daini Red Cross Hospital at least 6 months previously and had stable renal function for >3 months. Glomerular filtration rates (GFRs) were measured by inulin clearance (mGFR) and compared with estimated cystatin C-based GFRs (eGFRcys), estimated creatinine-based GFRs (eGFRcre) and their average values (eGFRave). Results: mGFR was 43.3 ± 14.1 mL/min/1.73 m2, eGFRcre was 39.6 ± 11.7, eGFRcys was 56.0 ± 17.1, and eGFRave was 47.8 ± 13.7 mL/min/1.73 m2. Serum cystatin C was 1.39 ± 0.37 mg/L and serum creatinine was 1.58 ± 0.51 mg/dL. The correlation coefficients between mGFR and eGFRcre, eGFRcys, and eGFRave were 0.768, 0.831, and 0.841, respectively (P < 0.001, for all).The intraclass correlation coefficients were 0.754, 0.816, and 0.840, respectively (P < 0.001, for all).The mean differences between measured and estimated GFR values were 3.74 mL/min/1.73 m2 with a root-mean square error (RMSE) of 9.06 for eGFRcre, +12.64 with RMSE of 9.48 for eGFRcys, and +4.45 with RMSE of 7.86 for eGFRave. Bland-Altman plots showed that eGFRcys overestimated GFR values compared with mGFR values in most cases and that eGFRave overestimated GFR values in 53 of 73 cases, whereas eGFRcre underestimated the values in 53 of 73 cases. Conclusion: eGFRave may be the best marker to estimate kidney function in Japanese renal transplant recipients with mildly reduced or normal kidney function.

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