HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort

Taro Kishi, Reiji Yoshimura, Tsuyoshi Kitajima, Tomo Okochi, Takenori Okumura, Tomoko Tsunoka, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Hiroshi Naitoh, Jun Nakamura, Norio Ozaki, Nakao Iwata

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of HTR2A with SSRI response in Japanese MDD patients, but the results were rather inconsistent and both studies had the problem of small sample sizes. Therefore, we conducted a replication association study using a sample larger than those in the two original Japanese studies (265 MDD patients), and found that four SNPs, two functional SNPs (-A1438G: rs6311 and T102C: rs6313) and two SNPs (rs7997012 and rs1928040) in HTR2A, were associated with the therapeutic response to SSRIs. HTR2A was associated with the therapeutic response SSRIs in Japanese MDD patients in a haplotype-wise analysis (Pall markers = 0.0136), and a significant association between rs1928040 in HTR2A and SSRI response was detected in MDD (Pallele-wise analysis = 0.0252). However, this significance disappeared after Bonferroni correction (P allele-wise analysis = 0.101). In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.

Original languageEnglish
Pages (from-to)237-242
Number of pages6
JournalNeuroMolecular Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 01-09-2010

Fingerprint

Major Depressive Disorder
Serotonin Uptake Inhibitors
Single Nucleotide Polymorphism
Receptor, Serotonin, 5-HT2A
Sample Size
Haplotypes
Therapeutics
Alleles
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Kishi, Taro ; Yoshimura, Reiji ; Kitajima, Tsuyoshi ; Okochi, Tomo ; Okumura, Takenori ; Tsunoka, Tomoko ; Yamanouchi, Yoshio ; Kinoshita, Yoko ; Kawashima, Kunihiro ; Naitoh, Hiroshi ; Nakamura, Jun ; Ozaki, Norio ; Iwata, Nakao. / HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort. In: NeuroMolecular Medicine. 2010 ; Vol. 12, No. 3. pp. 237-242.
@article{7042eac12bf04c348c18c4242db59a6c,
title = "HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort",
abstract = "Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of HTR2A with SSRI response in Japanese MDD patients, but the results were rather inconsistent and both studies had the problem of small sample sizes. Therefore, we conducted a replication association study using a sample larger than those in the two original Japanese studies (265 MDD patients), and found that four SNPs, two functional SNPs (-A1438G: rs6311 and T102C: rs6313) and two SNPs (rs7997012 and rs1928040) in HTR2A, were associated with the therapeutic response to SSRIs. HTR2A was associated with the therapeutic response SSRIs in Japanese MDD patients in a haplotype-wise analysis (Pall markers = 0.0136), and a significant association between rs1928040 in HTR2A and SSRI response was detected in MDD (Pallele-wise analysis = 0.0252). However, this significance disappeared after Bonferroni correction (P allele-wise analysis = 0.101). In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.",
author = "Taro Kishi and Reiji Yoshimura and Tsuyoshi Kitajima and Tomo Okochi and Takenori Okumura and Tomoko Tsunoka and Yoshio Yamanouchi and Yoko Kinoshita and Kunihiro Kawashima and Hiroshi Naitoh and Jun Nakamura and Norio Ozaki and Nakao Iwata",
year = "2010",
month = "9",
day = "1",
doi = "10.1007/s12017-009-8105-y",
language = "English",
volume = "12",
pages = "237--242",
journal = "NeuroMolecular Medicine",
issn = "1535-1084",
publisher = "Humana Press",
number = "3",

}

Kishi, T, Yoshimura, R, Kitajima, T, Okochi, T, Okumura, T, Tsunoka, T, Yamanouchi, Y, Kinoshita, Y, Kawashima, K, Naitoh, H, Nakamura, J, Ozaki, N & Iwata, N 2010, 'HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort', NeuroMolecular Medicine, vol. 12, no. 3, pp. 237-242. https://doi.org/10.1007/s12017-009-8105-y

HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort. / Kishi, Taro; Yoshimura, Reiji; Kitajima, Tsuyoshi; Okochi, Tomo; Okumura, Takenori; Tsunoka, Tomoko; Yamanouchi, Yoshio; Kinoshita, Yoko; Kawashima, Kunihiro; Naitoh, Hiroshi; Nakamura, Jun; Ozaki, Norio; Iwata, Nakao.

In: NeuroMolecular Medicine, Vol. 12, No. 3, 01.09.2010, p. 237-242.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HTR2A is associated with SSRI response in major depressive disorder in a Japanese Cohort

AU - Kishi, Taro

AU - Yoshimura, Reiji

AU - Kitajima, Tsuyoshi

AU - Okochi, Tomo

AU - Okumura, Takenori

AU - Tsunoka, Tomoko

AU - Yamanouchi, Yoshio

AU - Kinoshita, Yoko

AU - Kawashima, Kunihiro

AU - Naitoh, Hiroshi

AU - Nakamura, Jun

AU - Ozaki, Norio

AU - Iwata, Nakao

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of HTR2A with SSRI response in Japanese MDD patients, but the results were rather inconsistent and both studies had the problem of small sample sizes. Therefore, we conducted a replication association study using a sample larger than those in the two original Japanese studies (265 MDD patients), and found that four SNPs, two functional SNPs (-A1438G: rs6311 and T102C: rs6313) and two SNPs (rs7997012 and rs1928040) in HTR2A, were associated with the therapeutic response to SSRIs. HTR2A was associated with the therapeutic response SSRIs in Japanese MDD patients in a haplotype-wise analysis (Pall markers = 0.0136), and a significant association between rs1928040 in HTR2A and SSRI response was detected in MDD (Pallele-wise analysis = 0.0252). However, this significance disappeared after Bonferroni correction (P allele-wise analysis = 0.101). In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.

AB - Several recent investigations reported that the serotonin 2A receptor gene (HTR2A) was associated with selective serotonin reuptake inhibitors (SSRIs) in major depressive disorder. There have also been two reported association analyses of HTR2A with SSRI response in Japanese MDD patients, but the results were rather inconsistent and both studies had the problem of small sample sizes. Therefore, we conducted a replication association study using a sample larger than those in the two original Japanese studies (265 MDD patients), and found that four SNPs, two functional SNPs (-A1438G: rs6311 and T102C: rs6313) and two SNPs (rs7997012 and rs1928040) in HTR2A, were associated with the therapeutic response to SSRIs. HTR2A was associated with the therapeutic response SSRIs in Japanese MDD patients in a haplotype-wise analysis (Pall markers = 0.0136), and a significant association between rs1928040 in HTR2A and SSRI response was detected in MDD (Pallele-wise analysis = 0.0252). However, this significance disappeared after Bonferroni correction (P allele-wise analysis = 0.101). In conclusion, we suggest that HTR2A may play an important role in the pathophysiology of the therapeutic response to SSRIs in Japanese MDD patients. However, it will be important to replicate and confirm these findings in other independent studies using large samples.

UR - http://www.scopus.com/inward/record.url?scp=78649939577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78649939577&partnerID=8YFLogxK

U2 - 10.1007/s12017-009-8105-y

DO - 10.1007/s12017-009-8105-y

M3 - Article

C2 - 19937159

AN - SCOPUS:78649939577

VL - 12

SP - 237

EP - 242

JO - NeuroMolecular Medicine

JF - NeuroMolecular Medicine

SN - 1535-1084

IS - 3

ER -