Abstract
We examined a novel human feeder cell layer of mesenchymal stem cells harvested from human adipose tissues. Gene expression analyses and colony-forming assay with human primary epithelial cells showed that the adipose tissue-derived mesenchymal stem cells produced various factors to support epithelial stem/progenitor maintenance and cell growth. Using the mesenchymal stem cells as novel feeder layers, transplantable epithelial cell sheets could be effectively generated ex vivo on temperature-responsive cell-culture surfaces.
Original language | English |
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Pages (from-to) | 445-449 |
Number of pages | 5 |
Journal | Journal of Tissue Engineering and Regenerative Medicine |
Volume | 2 |
Issue number | 7 |
DOIs | |
Publication status | Published - 10-2008 |
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Biomaterials
- Biomedical Engineering