Human equilibrative nucleoside transporter 1 expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy

Reiko Yamada, Shugo Mizuno, Katsunori Uchida, Misao Yoneda, Kazuki Kanayama, Hiroyuki Inoue, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Masanobu Usui, Noriko Ii, Junya Tsuboi, Shunsuke Tano, Yasuhiko Hamada, Kyosuke Tanaka, Noriyuki Horiki, Toru Ogura, Taizo Shiraishi, Yoshiyuki Takei, Naoyuki KatayamaShuji Isaji

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Objectives: This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) and to validate the utility of hENT1 expression using EUSFNAB samples as a prognostic marker. Methods: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in 51 of 76 patients with PDAC who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. Results: The concordance rate of hENT1 expressions was 89.2% (K = 0.681). Median survival time (month) in the 51 whole patients and 37 patients with resection was significantly longer in hENT1 positive than in hENT1 negative: 25.0 and 30.0 versus 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than hENT1-negative patients, whose prognosis was similar to those without resection. Conclusions: The assessment of hENT1 expression using EUS-FNAB samples before Gem-CRT provides important information on patients with PDAC who can benefit from curative-intent resection.

Original languageEnglish
Pages (from-to)761-771
Number of pages11
JournalPancreas
Volume45
Issue number5
DOIs
Publication statusPublished - 2016

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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