Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis

Tetsushi Yoshikawa, T. Nakashima, S. Suga, Y. Asano, T. Yazaki, H. Kimura, T. Morishima, K. Kondo, K. Yamanishi

Research output: Contribution to journalArticle

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Abstract

The involvement of human herpesvirus-6 (HHV-6) and herpes simplex virus infections was evaluated virologically and serologically in a 13-month-old girl with meningoencephalitic illness occurring in the pre-eruptive stage of exanthem subitum. An isolation of HHV-6 from blood and seroconversion to the virus confirmed the primary infection with the virus. HHV-6 gene sequences were detected in cerebrospinal fluid of acute stage of the disease by polymerase chain reaction. There was no evidence of herpes simplex virus infection in blood and cerebrospinal fluid. The patient recovered from the disease without any sequelae, although abnormal electroencephalography and cerebral computed tomography findings were observed temporally in the acute stage of the disease. These findings strongly suggest that HHV-6 invades the central nervous system and causes meningoencephalitis.

Original languageEnglish
Pages (from-to)888-890
Number of pages3
JournalPediatrics
Volume89
Issue number5
Publication statusPublished - 01-01-1992

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Human Herpesvirus 6
Meningoencephalitis
Exanthema
Cerebrospinal Fluid
Virus Diseases
DNA
Acute Disease
Simplexvirus
Electroencephalography
Central Nervous System
Tomography
Viruses
Polymerase Chain Reaction
Genes

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Yoshikawa, T., Nakashima, T., Suga, S., Asano, Y., Yazaki, T., Kimura, H., ... Yamanishi, K. (1992). Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Pediatrics, 89(5), 888-890.
Yoshikawa, Tetsushi ; Nakashima, T. ; Suga, S. ; Asano, Y. ; Yazaki, T. ; Kimura, H. ; Morishima, T. ; Kondo, K. ; Yamanishi, K. / Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. In: Pediatrics. 1992 ; Vol. 89, No. 5. pp. 888-890.
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Yoshikawa, T, Nakashima, T, Suga, S, Asano, Y, Yazaki, T, Kimura, H, Morishima, T, Kondo, K & Yamanishi, K 1992, 'Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis', Pediatrics, vol. 89, no. 5, pp. 888-890.

Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. / Yoshikawa, Tetsushi; Nakashima, T.; Suga, S.; Asano, Y.; Yazaki, T.; Kimura, H.; Morishima, T.; Kondo, K.; Yamanishi, K.

In: Pediatrics, Vol. 89, No. 5, 01.01.1992, p. 888-890.

Research output: Contribution to journalArticle

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AU - Yoshikawa, Tetsushi

AU - Nakashima, T.

AU - Suga, S.

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AU - Yazaki, T.

AU - Kimura, H.

AU - Morishima, T.

AU - Kondo, K.

AU - Yamanishi, K.

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AB - The involvement of human herpesvirus-6 (HHV-6) and herpes simplex virus infections was evaluated virologically and serologically in a 13-month-old girl with meningoencephalitic illness occurring in the pre-eruptive stage of exanthem subitum. An isolation of HHV-6 from blood and seroconversion to the virus confirmed the primary infection with the virus. HHV-6 gene sequences were detected in cerebrospinal fluid of acute stage of the disease by polymerase chain reaction. There was no evidence of herpes simplex virus infection in blood and cerebrospinal fluid. The patient recovered from the disease without any sequelae, although abnormal electroencephalography and cerebral computed tomography findings were observed temporally in the acute stage of the disease. These findings strongly suggest that HHV-6 invades the central nervous system and causes meningoencephalitis.

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Yoshikawa T, Nakashima T, Suga S, Asano Y, Yazaki T, Kimura H et al. Human herpesvirus-6 DNA in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis. Pediatrics. 1992 Jan 1;89(5):888-890.