Human herpesvirus-6 infection and bone marrow transplantation

Tetsushi Yoshikawa, Seiji Kojima, Yoshizo Asano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Human herpesvirus-6 (HHV-6) is ubiquitous in the human population and causes exanthem subitum, a benign disease seen in infancy. However it also produces a wide spectrum of clinical manifestations including cases with a fatal outcome. The virus remains latent in several organs, including the kidneys, liver, lymph/nodes and salivary glands, after the primary infection and reactivates when immune function is impaired. Reactivation of the virus occurred in a half of the bone marrow recipients 2 to 4 weeks after bone marrow transplantation (BMT). It remains to be established whether HHV-6 in fact causes the fever and rash observed in recipients who have reactivation of the virus. The data reviewed here will be required to compare with those of human herpesvirus 7 and a different group of HHV-6.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalLeukemia and Lymphoma
Issue number1-2
Publication statusPublished - 1992

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research


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