Human herpesvirus-6 infection in bone marrow transplantation

T. Yoshikawa, S. Suga, Y. Asano, T. Nakashima, T. Yazaki, R. Sobue, M. Hirano, M. Fukuda, S. Kojima, T. Matsuyama

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Abstract

Twenty-five pediatric patients who received bone marrow transplantation (BMT) were studied prospectively to determine the relationship between BMT and human herpesvirus-6 (HHV-6) infection by the virus isolation from peripheral blood and/or bone marrow and by determining neutralizing antibodies to HHV-6 during the 2 months following BMT. All of the 25 donors and the recipients were immune to HHV-6 at the time of BMT and the virus was not isolated from them. HHV-6 was isolated from peripheral blood and/or bone marrow mononuclear cells in ten (40%) of the 25 recipients between day 14 and day 22 of BMT, but not from any other day. Two additional recipients showed a significant increase in the antibody titer. Thus, infection with HHV-6 was confirmed in 12 (48%) of the 25 recipients. Four of the 12 developed skin rashes; three of these four had a febrile episode when the virus was isolated, whereas none of the remaining 13 developed the skin rash. These results suggest a frequent infection with HHV-6 only a few weeks after BMT and a close association between the infection with the virus and the development of skin rashes.

Original languageEnglish
Pages (from-to)1381-1384
Number of pages4
JournalBlood
Volume78
Issue number5
Publication statusPublished - 01-01-1991

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Human Herpesvirus 6
Herpesviridae Infections
Bone Marrow Transplantation
Bone
Exanthema
Viruses
Skin
Blood
Virus Diseases
Infection
Neutralizing Antibodies
Bone Marrow Cells
Pediatrics
Fever
Bone Marrow
Tissue Donors
Antibodies

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Sobue, R., ... Matsuyama, T. (1991). Human herpesvirus-6 infection in bone marrow transplantation. Blood, 78(5), 1381-1384.
Yoshikawa, T. ; Suga, S. ; Asano, Y. ; Nakashima, T. ; Yazaki, T. ; Sobue, R. ; Hirano, M. ; Fukuda, M. ; Kojima, S. ; Matsuyama, T. / Human herpesvirus-6 infection in bone marrow transplantation. In: Blood. 1991 ; Vol. 78, No. 5. pp. 1381-1384.
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Yoshikawa, T, Suga, S, Asano, Y, Nakashima, T, Yazaki, T, Sobue, R, Hirano, M, Fukuda, M, Kojima, S & Matsuyama, T 1991, 'Human herpesvirus-6 infection in bone marrow transplantation', Blood, vol. 78, no. 5, pp. 1381-1384.

Human herpesvirus-6 infection in bone marrow transplantation. / Yoshikawa, T.; Suga, S.; Asano, Y.; Nakashima, T.; Yazaki, T.; Sobue, R.; Hirano, M.; Fukuda, M.; Kojima, S.; Matsuyama, T.

In: Blood, Vol. 78, No. 5, 01.01.1991, p. 1381-1384.

Research output: Contribution to journalArticle

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Yoshikawa T, Suga S, Asano Y, Nakashima T, Yazaki T, Sobue R et al. Human herpesvirus-6 infection in bone marrow transplantation. Blood. 1991 Jan 1;78(5):1381-1384.