Human herpesvirus 6 latently infects mononuclear cells but not liver tissue

Tetsushi Yoshikawa, Kyoko Suzuki, Masaru Ihira, Hiroshi Furukawa, Sadao Suga, Takuya Iwasaki, Takeshi Kurata, Katsuhiro Asonuma, Koichi Tanaka, Yoshizo Asano

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Aim - To investigate whether human herpesvirus 6 (HHV-6) can cause latent infection of liver tissue. Methods - Peripheral blood and liver tissue were coRRected from 25 living related liver transplant recipients at the time of transplantation. An avidin-biotin complex peroxidase method was used to identify HHV-6 antigen in the liver tissue. A nested polymerase chain reaction (PCR) was used to detect HHV-6 DNA in the liver tissue and mononuclear cells. Variant of HHV-6 was determined by the presence of the Hind III site in a second PCR product. Results - Immunohistochemical analysis for HHV-6 antigen was negative in all the liver specimens. HHV-6 DNA was not detected in liver tissue. Virus DNA was detected in peripheral blood mononuclear cells in nine of 25 recipients. All nine HHV-6 identified in the mononuclear cells were variant B. Conclusions - HHV-6 variant B latently infects mononuclear cells but not liver tissue.

Original languageEnglish
Pages (from-to)65-67
Number of pages3
JournalJournal of Clinical Pathology
Issue number1
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine


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