Human herpesvirus 6 reactivation and inflammatory cytokine production in patients with drug-induced hypersensitivity syndrome.

Tetsushi Yoshikawa, Ayano Fujita, Akiko Yagami, Kayoko Suzuki, Kayoko Matsunaga, Masaru Ihira, Yoshizo Asano

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

BACKGROUND: Human herpesvirus 6 (HHV-6) reactivation has been suggested to modify the clinical features of drug induced hypersensitivity syndrome (DIHS). However, mechanisms for viral reactivation and modification of the clinical features remain unclear. OBJECTIVE: To determine whether cytokines play an important role in viral reactivation and modification of the clinical features. STUDY DESIGN: We examined the kinetics of serum cytokines and viral load in HHV-6 infections of six patients with DIHS. RESULTS: HHV-6 infection occurred three to four weeks after the onset of disease. Elevated TNF-alpha and IL-6 levels were observed to precede HHV-6 infection in four of the six patients. Although high levels of IL-6 were observed in samples collected prior to HHV-6 infection, the amounts of this cytokine significantly decreased to undetectable levels during viral infection in five of the six patients. Subsequently, serum IL-6 levels were increased after viral infection in five patients. IL-1beta levels were also increased at the time of viral infection in three of the six patients. Neither IL-4 nor IFN-gamma could be detected in any of the samples. CONCLUSION: These results demonstrate that cytokines play an important role in HHV-6 reactivation in patients with DIHS.

Original languageEnglish
Pages (from-to)S92-96
JournalJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Volume37 Suppl 1
DOIs
Publication statusPublished - 12-2006

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

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